121 publication(s) trouvée(s)
Article scientifique
MicroRNA miR-214 Inhibits Snakehead Vesiculovirus Replication by Promoting IFN-α Expression via Targeting Host Adenosine 5′-Monophosphate-Activated Protein Kinase
Background: Snakehead vesiculovirus (SHVV), a new rhabdovirus isolated from diseased hybrid snakehead, has emerged as an important pathogen during the …
Article scientifique
A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country
Shigellosis is a mild-to-severe diarrheal infection caused by the genus Shigella and responsible for significant morbidity and mortality worldwide. We …
Article scientifique
Tumor Necrosis Factor-Alpha Targeting Can Protect against Arthritis with Low Sensitization to Infection
Tumor necrosis factor-alpha (TNF-alpha) blockade is an effective treatment for rheumatoid arthritis (RA) and other inflammatory diseases, but in patients, …
Article scientifique
Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency
Primary immunodeficiency disorders (PIDs) render patients vulnerable to infection with a wide range of microorganisms, and thus provide good in …
Article scientifique
Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review
Ramadan is the ninth month of the Islamic lunar calendar and is observed by Muslims as a month of fasting. …
Article scientifique
IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice
Experimental infection with the protozoan parasite Leishmania major has been extensively used to understand the mechanisms involved in T helper …
Article scientifique
Assessment of the Combined Effect of Epstein–Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach
Epstein-Barr virus (EBV) is a necessary cause of endemic Burkitt lymphoma (eBL), while the role of Plasmodium falciparum in eBL …
Article scientifique
SIgA, TGF-β1, IL-10, and TNFα in Colostrum Are Associated with Infant Group B Streptococcus Colonization
BACKGROUND: infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The …
Article scientifique
IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney
IL-36α, a member of the IL-1 family, is a crucial mediator of inflammatory responses. We previously found that IL-36α was …
Article scientifique
IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and γδ Cells in Tuberculosis Infection and Disease
IL-17 producing cells have been shown to be important in the early stages of Mycobacterium tuberculosis (Mtb) infection in animal …
Article scientifique
Ensuring Access to Immunoglobulin Therapies for People with Primary Immunodeficiency: A Need to Improve Individuals’ Quality of Life and the Sustainability of Health-care Systems
OPINION article Front. Immunol., 19 September 2017Sec. Primary Immunodeficiencies Volume 8 - 2017 | https://doi.org/10.3389/fimmu.2017.01165
Article scientifique
Cellular Architecture of Spinal Granulomas and the Immunological Response in Tuberculosis Patients Coinfected with HIV
Mycobacterium tuberculosis (M.tb) and HIV are individually responsible for the most deaths worldwide among all infectious agents, and co-infection with …
Article scientifique
Functional Analysis of Phagocyte Activity in Whole Blood from HIV/Tuberculosis-Infected Individuals Using a Novel Flow Cytometry-Based Assay
analysis is paramount to our understanding of those immune mechanisms that lead to protection or susceptibility against a broad range …
Article scientifique
New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells
Memory T-cells, particularly, effector memory T cells are implicated in the pathogenesis of inflammatory diseases and may contribute to tissue …
Article scientifique
Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial
OBJECTIVES: Early treatment of HIV-infected children and adults is important for optimal immune reconstitution. Infants' immune systems are more plastic …
Article scientifique
The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing
The only licensed vaccine against tuberculosis (TB), Bacille Calmette-Guérin (BCG), protects against severe extra pulmonary forms of TB but is …
Article scientifique
Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria–Tetanus–Pertussis Vaccine Implies a Regulatory Role
Regulatory T cells (Tregs) play a key homeostatic role by suppressing immune responses. They have been targeted in mouse and …
Article scientifique
Clinical Efficacy, Safety, and Immunogenicity of a Live Attenuated Tetravalent Dengue Vaccine (CYD-TDV) in Children: A Systematic Review with Meta-analysis
Background: Dengue haemorrhagic fever is the leading cause of hospitalisation and death in children living in Asia and Latin America. …
Article scientifique
The Activity of the Neutral Sphingomyelinase Is Important in T Cell Recruitment and Directional Migration
Breakdown of sphingomyelin as catalysed by the activity of sphingomyelinases profoundly affects biophysical properties of cellular membranes which is particularly …
Article scientifique
RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial
Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection …