123 publication(s) trouvée(s)
Article scientifique
The Activity of the Neutral Sphingomyelinase Is Important in T Cell Recruitment and Directional Migration
Breakdown of sphingomyelin as catalysed by the activity of sphingomyelinases profoundly affects biophysical properties of cellular membranes which is particularly …
Article scientifique
RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial
Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection …
Article scientifique
Analysis of the Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals
Several immune-based assays have been suggested to differentiate latent from active tuberculosis. However, their relative performance as well as their …
Article scientifique
Transcriptional Profiling of Midguts Prepared from Trypanosoma/T. congolense-Positive Glossina palpalis palpalis Collected from Two Distinct Cameroonian Foci: Coordinated Signatures of the Midguts’ Remodeling As T. congolense-Supportive Niches
Our previous transcriptomic analysis of Glossina palpalis gambiensis experimentally infected or not with Trypanosoma brucei gambiense aimed to detect differentially …
Article scientifique
Family History of Early Infant Death Correlates with Earlier Age at Diagnosis But Not Shorter Time to Diagnosis for Severe Combined Immunodeficiency
Background Severe combined immunodeficiency (SCID) is fatal unless treated with hematopoietic stem cell transplant. Delay in diagnosis is common without …
Article scientifique
Sequence-Based Genotyping of Expressed Swine Leukocyte Antigen Class I Alleles by Next-Generation Sequencing Reveal Novel Swine Leukocyte Antigen Class I Haplotypes and Alleles in Belgian, Danish, and Kenyan Fattening Pigs and Göttingen Minipigs
The need for typing of the swine leukocyte antigen (SLA) is increasing with the expanded use of pigs as models …
Article scientifique
Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes
A bidirectional communication between the immune and endocrine systems exists and facilitates optimum responses in the host during infections. This …
Article scientifique
Lessons from Genetic Studies of Primary Immunodeficiencies in a Highly Consanguineous Population
During the last decades, the study of primary immunodeficiencies (PIDs) has contributed tremendously to unravel novel pathways involved in a …
Article scientifique
Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication
Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may …
Article scientifique
Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review
Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies, …
Article scientifique
What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings
Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a …
Article scientifique
Myristoylation: An Important Protein Modification in the Immune Response
Protein N-myristoylation is a cotranslational lipidic modification specific to the alpha-amino group of an N-terminal glycine residue of many eukaryotic …
Article scientifique
High Sporozoite Antibody Titers in Conjunction with Microscopically Detectable Blood Infection Display Signatures of Protection from Clinical Malaria
Immuno-epidemiological studies typically reveal slow, age-dependent acquisition of immune responses against Plasmodium falciparum sporozoites. Naturally acquired immunity against pre-erythrocytic stages …
Article scientifique
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes
The antioxidant enzyme heme oxygenase-1 (HO-1) is implicated in the pathogenesis of tuberculosis (TB) and has been proposed as a …
Article scientifique
Regulatory T Cells and Pro-inflammatory Responses Predominate in Children with Tuberculosis
Background: Following infection with Mycobacterium tuberculosis (M.tb), children are more susceptible to develop disease, particularly extra-pulmonary disease, than adults. The …
Article scientifique
Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants’ Neutrophils—A Pilot Study
An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for …
Article scientifique
The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis
Plasma cells (PCs) are exposed to intense endoplasmic reticulum (ER) stress imposed by enormous rates of immunoglobulin (Ig) synthesis and …
Article scientifique
Monomeric Immunoglobulin A from Plasma Inhibits Human Th17 Responses In Vitro Independent of FcαRI and DC-SIGN
Circulating immunoglobulins including IgG and IgM play a critical role in the immune homeostasis by modulating functions of immune cells. …
Article scientifique
Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
The immune system and metabolism are highly integrated and multilevel interactions between metabolic system and T lymphocyte signaling and fate …
Article scientifique
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis
Tuberculosis of the central nervous system (CNS-TB) is a devastating complication of tuberculosis, and tumour necrosis factor (TNF) is crucial …