119 publication(s) trouvée(s)
Article scientifique
Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase
Schistosomes are intravascular parasitic platyhelminths that infect >200 million people globally. These long-lived parasites do not appear to provoke thrombus …
Article scientifique
Prostaglandin E2 Stimulates the Expansion of Regulatory Hematopoietic Stem and Progenitor Cells in Type 1 Diabetes
Hematopoietic stem and progenitor cells (HSPCs) are multipotent stem cells that have been harnessed as a curative therapy for patients …
Article scientifique
Trans-Allelic Model for Prediction of Peptide:MHC-II Interactions
Major histocompatibility complex class two {(MHC-II)} molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition …
Article scientifique
Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya
The potential consequences of parasitic infections on a person’s immune responsiveness to unrelated antigens are often conjectured upon in relationship …
Article scientifique
Herd Immunity to Ebolaviruses Is Not a Realistic Target for Current Vaccination Strategies
The recent West African Ebola virus pandemic, which affected >28,000 individuals increased interest in anti-Ebolavirus vaccination programs. Here, we systematically …
Article scientifique
Origin and Evolution of Dendritic Epidermal T Cells
Dendritic epidermal T cells (DETCs) expressing invariant Vγ5Vδ1 T-cell receptors play a crucial role in maintaining skin homeostasis in mice. …
Article scientifique
The Role of Optineurin in Antiviral Type I Interferon Production
After a viral infection and the stimulation of some pattern-recognition receptors as the toll-like receptor 3 in the endosomes or …
Article scientifique
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts
(MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and …
Article scientifique
Differential Effect of Viable Versus Necrotic Neutrophils on Mycobacterium tuberculosis Growth and Cytokine Induction in Whole Blood
Neutrophils exert both positive and negative influences on the host response to tuberculosis, but the mechanisms by which these differential …
Article scientifique
Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma
Immune checkpoint inhibitors (ICI) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets …
Article scientifique
Altered Toll-Like Receptor-4 Response to Lipopolysaccharides in Infants Exposed to HIV-1 and Its Preventive Therapy
Pathogen sensing and recognition through pattern recognition receptors, and subsequent production of proinflammatory cytokines, is the cornerstone of the innate …
Article scientifique
Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway
The use of serotype 5 adenovirus (Ad)-derived vectors in vaccination is confronted to preexisting anti-Ad immunity. Epitope display on Ad …
Article scientifique
Histopathological Correlations between Mediastinal Fat-Associated Lymphoid Clusters and the Development of Lung Inflammation and Fibrosis following Bleomycin Administration in Mice
Bleomycin (BLM) has been reported to induce lung inflammation and fibrosis in human and mice and showed genetic susceptibility. Interestingly, …
Article scientifique
Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity
(Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 …
Article scientifique
B and T Cell Phenotypic Profiles of African HIV-Infected and HIV-Exposed Uninfected Infants: Associations with Antibody Responses to the Pentavalent Rotavirus Vaccine
We examined associations between B and T cell phenotypic profiles and antibody responses to the pentavalent rotavirus vaccine (RV5) in …
Article scientifique
Detection of Pathogen Exposure in African Buffalo Using Non-Specific Markers of Inflammation
Detecting exposure to new or emerging pathogens is a critical challenge to protecting human, domestic animal and wildlife health. Yet …
Article scientifique
T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure
The introduction of non-breastmilk foods to HIV-infected infants is associated with increased levels of immune activation, which can impact the …
Article scientifique
The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum)
Mycobacterium bovis is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (Ceratotherium simum). Control …
Article scientifique
MicroRNA miR-214 Inhibits Snakehead Vesiculovirus Replication by Promoting IFN-α Expression via Targeting Host Adenosine 5′-Monophosphate-Activated Protein Kinase
Background: Snakehead vesiculovirus (SHVV), a new rhabdovirus isolated from diseased hybrid snakehead, has emerged as an important pathogen during the …
Article scientifique
A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country
Shigellosis is a mild-to-severe diarrheal infection caused by the genus Shigella and responsible for significant morbidity and mortality worldwide. We …