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A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts

Article scientifique 2018 Anglais

Résumé

(MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miRNAs) have been developed as biomarkers for other diseases. We performed machine-learning analysis of c-miRNA measurements in the serum of adult household contacts (HHCs) of TB index cases from South Africa and Uganda and developed a c-miRNA-based signature of risk for progression to active TB. This c-miRNA-based signature significantly discriminated HHCs within 6 months of progression to active disease from HHCs that remained healthy in an independent test set [ROC area under the ROC curve (AUC) 0.74, progressors < 6 Mo to active TB and ROC AUC 0.66, up to 24 Mo to active TB], and complements the predictions of a previous cellular mRNA-based signature of TB risk.

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Duffy, F., Thompson, E., Downing, K., Suliman, S., Mayanja‐Kizza, H., Boom, W., Thiel, B., Weiner, J., Kaufmann, S., Dover, D., Tabb, D., Dockrell, H., Ottenhoff, T., Tromp, G., Scriba, T., Zak, D., Walzl, G. (2018). A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts. https://doi.org/10.3389/fimmu.2018.00661

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Auteur(s)

Fergal J. Duffy Ethan Thompson Katrina Downing Sara Suliman Harriet Mayanja‐Kizza W. Henry Boom Bonnie Thiel January Weiner Stefan H. E. Kaufmann Drew Dover David L. Tabb Hazel M. Dockrell Tom H. M. Ottenhoff Gerard Tromp Thomas J. Scriba Daniel E. Zak Gerhard Walzl

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