119 publication(s) trouvée(s)
Article scientifique
Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG
-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity. Although the …
Article scientifique
The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity
Trained immunity describes the ability of innate immune cells to form immunological memories of prior encounters with pathogens. Recollection of …
Article scientifique
Type 3 ILCs in Lung Disease
The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from …
Article scientifique
Inflammatory Cytokine Profiles of Semen Influence Cytokine Responses of Cervicovaginal Epithelial Cells
Genital inflammatory cytokine responses increase HIV risk. Since male partner semen is a complex mixture of immune-modulatory prostaglandins and cytokines, …
Article scientifique
Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection
Soil-transmitted helminths and Mycobacterium tuberculosis frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) …
Article scientifique
Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells
Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response. …
Article scientifique
Refining Diagnosis of Schistosoma haematobium Infections: Antigen and Antibody Detection in Urine
Background: Traditional microscopic examination of urine or stool for schistosome eggs lacks sensitivity compared to measurement of schistosome worm-derived circulating …
Article scientifique
Host Regulators of Liver Fibrosis During Human Schistosomiasis
Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical …
Article scientifique
Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion
Identifying a blood circulating cellular biomarker that can be used to assess severity of disease and predict the time to …
Article scientifique
Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon
Background and Methods: Schistosomiasis is debilitating and reported to impair immune responsiveness of infected hosts. In Cameroon, mass drug administration …
Article scientifique
Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis
Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis of active TB is hampered by the lack …
Article scientifique
HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected With Schistosoma spp. After Adjustment for Duration of HIV-1 Infection
Studies of the role of Schistosoma co-infections on plasma HIV-1 RNA (HIV-1 viral load) have yielded incongruent results. The role …
Article scientifique
Variation in the Untranslated Genome and Susceptibility to Infections
The clinical outcomes of infections are highly variable among individuals and are determined by complex host-pathogen interactions. Genome-wide association studies …
Article scientifique
Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses
Innate antiviral immunity establishes first line of defence against invading pathogens through sensing their molecular structures such as viral RNA. …
Article scientifique
IL-22: An Underestimated Player in Natural Resistance to Tuberculosis?
(Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune responses are crucial …
Article scientifique
Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy
Background: The analysis of phenotypic characteristics on Mycobacterium tuberculosis (MTB)-specific T cells is a promising approach for the diagnosis of …
Article scientifique
The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris—Analysis of Four Different Ethnic Cohorts
IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of …
Article scientifique
Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle
A better understanding of stable changes in regulation of gene expression that result from epigenetic events is of great relevance …
Article scientifique
Susceptibility to Tuberculosis Is Associated With PI3K-Dependent Increased Mobilization of Neutrophils
Neutrophilia is a condition commonly observed in patients with late-stage tuberculosis, but evidence suggests that increased neutrophil influx begins early …
Article scientifique
Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Mycobacterium tuberculosis Infection
Background: It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between …