3614
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Biologie synthétique
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Publications
3614 publication(s) trouvée(s)
Article scientifique
Saussurea lappa Clarke extract exhibits potent antioxidant effect and attenuates neuroinflammatory responses in lipopolysaccharide-stimulated microglial cells
Purpose: To investigate the antioxidant and anti-neuroinflammatory potential of Saussurea lappa Clarke (SLC-EA) extract in LPS-stimulated BV-2 microglial cells.Methods: Cell …
Article scientifique
Prevalence of plasmid-mediated AmpC beta-lactamases in Enterobacteria isolated from urban and rural folks in Uganda
Background : AmpC beta-lactamase-producing bacteria are associated with increased resistance to third-generation cephalosporins. Here, we describe plasmid-mediated AmpC beta-lactamase-producing enterobacteria …
Article scientifique
Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles
As the genomic profile across cancers varies from person to person, patient prognosis and treatment may differ based on the …
Article scientifique
Functional characterisation of the transcriptome from leaf tissue of the fluoroacetate-producing plant, Dichapetalum cymosum, in response to mechanical wounding
Dichapetalum cymosum produces the toxic fluorinated metabolite, fluoroacetate, presumably as a defence mechanism. Given the rarity of fluorinated metabolites in …
Article scientifique
In silico design and validation of a highly degenerate primer pair: a systematic approach
BACKGROUND: The techniques of amplifying genetic materials have enabled the extensive study of several biological activities outside the biological milieu …
Article scientifique
Tamoxifen induces hypercoagulation and alterations in ERα and ERβ dependent on breast cancer sub-phenotype ex vivo
Tamoxifen shows efficacy in reducing breast cancer-related mortality but clinically, is associated with increased risk for thromboembolic events. We aimed …
Article scientifique
Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
BACKGROUND: Plasmodial transketolase (PTKT) enzyme is one of the novel pharmacological targets being explored as potential anti-malarial drug target due …
Article scientifique
Western influenced lifestyle and Kv2.1 association as predicted biomarkers for Tunisian colorectal cancer
BACKGROUND: Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with …
Article scientifique
Antioxidant or pro-oxidant and glutathione transferase P1-1 inhibiting activities for Tamarindus indica seeds and their cytotoxic effect on MCF-7 cancer cell line
The multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment. Glutathione S-transferase Pi (GSTP1-1) catalyzes the …
Article scientifique
Identification of Novel BRCA1 and RAD50 Mutations Associated With Breast Cancer Predisposition in Tunisian Patients
Background Deleterious mutations on BRCA1/2 genes are known to confer high risk of developing breast and ovarian cancers. The identification …
Article scientifique
Estimation of co-variance components, genetic parameters, and genetic trends of reproductive traits in community-based breeding program of Bonga sheep in Ethiopia
OBJECTIVE: The objectives of the study were to evaluate reproductive performance and selection response through genetic trend of community-based breeding …
Article scientifique
Shifts in microbial diversity, composition, and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys
BACKGROUND: The microbiota plays an important role in HIV pathogenesis in humans. Microbiota can impact health through several pathways such …
Article scientifique
Carriage of ESBL-producing Gram-negative bacteria by flies captured in a hospital and its suburban surroundings in Ethiopia
BACKGROUND: Local data from the Asella Teaching and Referral Hospital in the town of Asella, Ethiopia reveal a high prevalence …
Article scientifique
Molecular characterization of beta-lactamase genes produced by community-acquired uropathogenic Escherichia coli in Nouna
INTRODUCTION: Extended-Spectrum Beta-Lactamases (ESBL) are a common mechanism of bacterial resistance in Enterobacteriaceae. The purpose of this study is to …
Article scientifique
Patulin suppresses α1-adrenergic receptor expression in HEK293 cells
Abstract Patulin (PAT) is a common mycotoxin contaminant of apple products linked to impaired metabolic and kidney function. Adenosine monophosphate …
Article scientifique
Novel Leu-Val Based Dipeptide as Antimicrobial and Antimalarial Agents: Synthesis and Molecular Docking
The increase of antimicrobial resistance (AMR) and antimalarial resistance are complex and severe health issues today, as many microbial strains …
Article scientifique
Knowledge, attitude and practice towards anthrax in northern Ethiopia: a mixed approach study
BACKGROUND: Anthrax is the second most highly prioritized zoonotic disease in Ethiopia due to its negative impact at the household …
Article scientifique
Incidence and predictors of diabetic ketoacidosis among children with diabetes in west and east Gojjam zone referral hospitals, northern Ethiopia, 2019
BACKGROUND: Recurrent diabetic ketoacidosis in patients with known diabetes mellitus remains a relevant problem in pediatrics with an incidence of …
Article scientifique
Breast cancer in togolese women: immunohistochemistry subtypes
BACKGROUND: Molecular classification of breast cancer is an important factor for prognostic and clinical outcomes. There are no data regarding …
Article scientifique
A multi-disciplinary comparison of great ape gut microbiota in a central African forest and European zoo
Comparisons of mammalian gut microbiota across different environmental conditions shed light on the diversity and composition of gut bacteriome and …