Sciences de la vie et biotechnologies

Article scientifique

The H3ABioNet helpdesk: an online bioinformatics resource, enhancing Africa’s capacity for genomics research

BACKGROUND: Currently, formal mechanisms for bioinformatics support are limited. The H3Africa Bioinformatics Network has implemented a public and freely available …

2019 Open Access

Article scientifique

Backward compatibility of whole genome sequencing data with MLVA typing using a new MLVAtype shiny application for Vibrio cholerae

BACKGROUND: Multiple-Locus Variable Number of Tandem Repeats (VNTR) Analysis (MLVA) is widely used by laboratory-based surveillance networks for subtyping pathogens …

2019 Open Access

Article scientifique

Comparing alternative cholera vaccination strategies in Maela refugee camp: using a transmission model in public health practice

BACKGROUND: Cholera is a major public health concern in displaced-person camps, which often contend with overcrowding and scarcity of resources. …

2019 Open Access

Article scientifique

A large self-transmissible resistance plasmid from Nigeria contains genes that ameliorate a carrying cost

Abstract Antimicrobial resistance is rapidly expanding, in a large part due to mobile genetic elements. We screened 94 fecal fluoroquinolone-resistant …

2019 Open Access

Article scientifique

Acetogenic Fermentation From Oxygen Containing Waste Gas

The microbial production of bulk chemicals from waste gas is becoming a pertinent alternative to industrial strategies that rely on …

2019 Open Access

Article scientifique

The Role of Stem Cell Factor in Hyperpigmented Skin Lesions

BACKGROUND: Skin hyperpigmentation usually results from an increased number, or activity, of melanocytes. The degree of pigmentation of skin depends …

2019 Open Access

Article scientifique

Introgression of a cry1Ab transgene into open pollinated maize and its effect on Cry protein concentration and target pest survival

In Africa, the target pests of genetically modified Bt maize are lepidopteran stem borers, notably Busseola fusca (Lepidoptera: Noctuidae). Gene …

2019 Open Access

Article scientifique

Osteogenesis imperfecta and pregnancy: a case report

BACKGROUND: Osteogenesis imperfecta is a rare connective tissue disorder of varying phenotypic presentations. In pregnancies complicated by osteogenesis imperfecta, there …

2019 Open Access

Article scientifique

Morphological and physiological characteristics of claw quality in South African Bonsmara cattle

Sound claws are essential for beef cattle, given the marked influence they have on functional longevity and subsequent performance. The …

2019 Open Access

Article scientifique

The Plant Pathogenic Bacterium Streptomyces scabies Degrades the Aromatic Components of Potato Periderm via the β-Ketoadipate Pathway

The outer potato periderm layer consists of dead suberized cells. Suberin, a protective biopolymer, is made of a polyaliphatic portion …

2019 Open Access

Article scientifique

Assessment of the Diagnostic Potential of miR-29a-3p and miR-92a-3p as Circulatory Biomarkers in Acute Myeloid Leukemia

BACKGROUND: Acute myeloid leukemia (AML) is a set of Myeloproliferative neoplasms that are identified by excessive growth of myeloid blasts …

2019 Open Access

Article scientifique

Identifying sequence variants contributing to hereditary breast and ovarian cancer in BRCA1 and BRCA2 negative breast and ovarian cancer patients

Families with breast and ovarian cancer are often tested for disease associated sequence variants in BRCA1 and BRCA2. Pathogenic sequence …

2019 Open Access

Article scientifique

Virus-based pharmaceutical production in plants: an opportunity to reduce health problems in Africa

BACKGROUND: Developing African countries face health problems that they struggle to solve. The major causes of this situation are high …

2019 Open Access

Article scientifique

Investigation of potential pathogenicity of Willaertia magna by investigating the transfer of bacteria pathogenicity genes into its genome

Willaertia magna c2c maky is a thermophilic amoeba closely related to the genus Naegleria. This free-living amoeba has the ability …

2019 Open Access

Article scientifique

BayesMetab: treatment of missing values in metabolomic studies using a Bayesian modeling approach

BACKGROUND: With the rise of metabolomics, the development of methods to address analytical challenges in the analysis of metabolomics data …

2019 Open Access

Article scientifique

Microbial Diversity in Bushmeat Samples Recovered from the Serengeti Ecosystem in Tanzania

Bushmeat, the meat and organs derived from wildlife species, is a common source of animal protein in the diets of …

2019 Open Access

Article scientifique

vhcub: Virus-host codon usage co-adaptation analysis

Viruses show noticeable evolution to adapt and reproduce within their hosts. Theoretically, patterns and factors that affect the codon usage …

2019 Open Access

Article scientifique

The alternative cap-binding complex is required for antiviral defense in vivo

Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression …

2019 Open Access

Article scientifique

PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells

BACKGROUND: Spermatogonial stem cells (SSCs) are the cornerstone of sperm production and thus perpetual male fertility. In clinics, transplantation of …

2019 Open Access

Article scientifique

Characterization of Holstein and Normande whole milk miRNomes highlights breed specificities

The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to …

2019 Open Access