4595
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Biologie synthétique
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Publications
4595 publication(s) trouvée(s)
Article scientifique
An efficient approach to BAC based assembly of complex genomes
BACKGROUND: There has been an exponential growth in the number of genome sequencing projects since the introduction of next generation …
Article scientifique
Organ-Specific Quantitative Genetics and Candidate Genes of Phenylpropanoid Metabolism in Brassica oleracea
Phenolic compounds are proving to be increasingly important for human health and in crop development, defense and adaptation. In spite …
Article scientifique
Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far
Metformin is known as a hypoglycaemic agent that regulates glucose homeostasis by inhibiting liver glucose production and increasing muscle glucose …
Article scientifique
Toxicological study of the butanol fractionated root extract of Asparagus africanus Lam., on some blood parameter and histopathology of liver and kidney in mice
BACKGROUND: The butanol fractionated root extract of Asparagus africanus Lam., a traditional herb widely used to treat various ailments were …
Article scientifique
Epigenetic Pattern on the Human Y Chromosome Is Evolutionarily Conserved
DNA methylation plays an important role for mammalian development. However, it is unclear whether the DNA methylation pattern is evolutionarily …
Article scientifique
Assessing the knowledge, attitudes and practices regarding cholera preparedness and prevention in Ga-Mampuru village, Limpopo, South Africa
The study assessed the knowledge, attitudes and practices of cholera prevention and preparedness in Ga-Mampuru village (Limpopo, South Africa). Interviewers …
Article scientifique
The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
BACKGROUND: The receptor for advanced glycation end products (RAGE) has been found to interact with amyloid β (Aβ). Although RAGE …
Article scientifique
Is there a role of pharmacogenomics in Africa
Pharmacogenomics has the potential of transforming clinical research and improving healthcare in sub-Saharan Africa (SSA). The role of African genome …
Article scientifique
Inhibition of NF-ĸB, Bcl-2 and COX-2 Gene Expression by an Extract of Eruca sativa Seeds during Rat Mammary Gland Carcinogenesis
The effect of Eruca sativa seed extract (SE) on nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) …
Article scientifique
Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy
BACKGROUND: Hepato-carcinogenesis is multifaceted in its molecular aspects. Among the interplaying agents are altered gap junctions, the proteasome/autophagy system, and …
Article scientifique
H3Africa multi-centre study of the prevalence and environmental and genetic determinants of type 2 diabetes in sub-Saharan Africa: study protocol
The burden and aetiology of type 2 diabetes (T2D) and its microvascular complications may be influenced by varying behavioural and …
Article scientifique
Evaluation in Cameroon of a Novel, Simplified Methodology to Assist Molecular Microbiological Analysis of V. cholerae in Resource-Limited Settings
BACKGROUND: Vibrio cholerae is endemic in South Asia and Africa where outbreaks of cholera occur widely and are particularly associated …
Article scientifique
Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum
BACKGROUND: Small RNAs (sRNAs) have emerged as important regulatory molecules and have been studied in several bacteria. However, to date, …
Article scientifique
Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin
BACKGROUND & AIMS: Recently, we reported that liver Label Retaining Cancer Cells (LRCC) can initiate tumors with only 10 cells …
Article scientifique
Genetic diversity of lactase persistence in East African populations
BACKGROUND: The expression of lactase which digests lactose from milk in humans is generally lost after weaning, but selected mutations …
Article scientifique
Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks
BACKGROUND: Differential networks have recently been introduced as a powerful way to study the dynamic rewiring capabilities of an interactome …
Article scientifique
Multivalent Targeting Based Delivery of Therapeutic Peptide using AP1-ELP Carrier for Effective Cancer Therapy
Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of …
Article scientifique
Plasma Circulating Cell-free Nuclear and Mitochondrial DNA as Potential Biomarkers in the Peripheral Blood of Breast Cancer Patients
BACKGROUND: In Egypt, breast cancer is estimated to be the most common cancer among females. It is also a leading …
Article scientifique
TRAPLINE: a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation
BACKGROUND: Technical advances in Next Generation Sequencing (NGS) provide a means to acquire deeper insights into cellular functions. The lack …
Article scientifique
Gut Microbiota in Children Hospitalized with Oedematous and Non-Oedematous Severe Acute Malnutrition in Uganda
BACKGROUND: Severe acute malnutrition (SAM) among children remains a major health problem in many developing countries. SAM manifests in both …