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Epigenetic Pattern on the Human Y Chromosome Is Evolutionarily Conserved

Article scientifique 2016 Anglais

Résumé

DNA methylation plays an important role for mammalian development. However, it is unclear whether the DNA methylation pattern is evolutionarily conserved. The Y chromosome serves as a powerful tool for the study of human evolution because it is transferred between males. In this study, based on deep-rooted pedigrees and the latest Y chromosome phylogenetic tree, we performed epigenetic pattern analysis of the Y chromosome from 72 donors. By comparing their respective DNA methylation level, we found that the DNA methylation pattern on the Y chromosome was stable among family members and haplogroups. Interestingly, two haplogroup-specific methylation sites were found, which were both genotype-dependent. Moreover, the African and Asian samples also had similar DNA methylation pattern with a remote divergence time. Our findings indicated that the DNA methylation pattern on the Y chromosome was conservative during human male history.

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Zhang, M., Wang, C., Yang, C., Hao, M., Agbagwa, I., Wang, L., Wang, Y., Yan, S., Ren, S., Sun, Y., Pei, G., Liu, X., Liu, J., Li, J., Li, H., Sun, Y. (2016). Epigenetic Pattern on the Human Y Chromosome Is Evolutionarily Conserved. https://doi.org/10.1371/journal.pone.0146402

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Auteur(s)

Minjie Zhang Chuan‐Chao Wang Caiyun Yang Meng Hao Ikechukwu O. Agbagwa Ling-Xiang Wang Yingzhi Wang Shi Yan Shancheng Ren Yinghao Sun Gang Pei Xin Liu Jiang Liu Jin Li Hui Li Yingli Sun

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