67 publication(s) trouvée(s)
Article scientifique
From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib
Sunitinib, a multityrosine kinase inhibitor, is currently the standard first-line therapy in metastatic renal cell carcinoma (mRCC) and is also …
Article scientifique
Effects of Gladiolus dalenii on the Stress-Induced Behavioral, Neurochemical, and Reproductive Changes in Rats
Gladiolus dalenii is a plant commonly used in many regions of Cameroon as a cure for various diseases like headaches, …
Article scientifique
Wound Healing Properties of Selected Plants Used in Ethnoveterinary Medicine
Plants have arrays of phytoconstituents that have wide ranging biological effects like antioxidant, anti-inflammatory and antimicrobial properties key in wound …
Article scientifique
Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation
Background and Objective: Sphingosine 1-Phosphate (S1P), and S1P receptor modulator fingolimod have been suggested to play important cardioprotective role in …
Article scientifique
Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles
Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the …
Article scientifique
Date Palm (Phoenix dactylifera) Fruits as a Potential Cardioprotective Agent: The Role of Circulating Progenitor Cells
phenolic compounds Abstract Context: Date palms, along with their fruits' dietary consumption, possess enormous medicinal and pharmacological activities manifested in …
Article scientifique
Review of the Reported Measures of Clinical Validity and Clinical Utility as Arguments for the Implementation of Pharmacogenetic Testing: A Case Study of Statin-Induced Muscle Toxicity
Advances from pharmacogenetics (PGx) have not been implemented into health care to the expected extent. One gap that will be …
Article scientifique
Pharmacokinetic/Pharmacodynamic Modeling of Tulathromycin against Pasteurella multocida in a Porcine Tissue Cage Model
Tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. The aim of our …
Article scientifique
Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy
In this study, we investigated antiepileptogenic and neuroprotective effects of the aqueous extract of Pergularia daemia roots (PDR) using in …
Article scientifique
Alantolactone Improves Prolonged Exposure of Interleukin-6-Induced Skeletal Muscle Inflammation Associated Glucose Intolerance and Insulin Resistance
The pro-inflammatory cytokine, IL-6, has been proposed to be one of the mediators that link chronic inflammation to glucose intolerance …
Article scientifique
Anti-allergic Hydroxy Fatty Acids from Typhonium blumei Explored through ChemGPS-NP
Increasing prevalence of allergic diseases with an inadequate variety of treatment drives forward search for new alternative drugs. Fatty acids, …
Article scientifique
Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients
Metabolic syndrome is a cluster of three or more metabolic disorders including insulin resistance, obesity, and hyperlipidemia. Obesity has become …
Article scientifique
North African Medicinal Plants Traditionally Used in Cancer Therapy
Background: Cancer is a major cause of mortality worldwide with increasing numbers by the years. In North Africa, the number …
Article scientifique
Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets
Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year …
Article scientifique
Neuronal Voltage Gated Potassium Channels May Modulate Nitric Oxide Synthesis in Corpus Cavernosum
Potassium channels (K+Ch) in corpus cavernosum play an important role in the regulation of erection. Nitric oxide (NO) acts through …
Article scientifique
BGP-15 Protects against Oxaliplatin-Induced Skeletal Myopathy and Mitochondrial Reactive Oxygen Species Production in Mice
Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has a multitude of deleterious side-effects including skeletal muscle …
Article scientifique
Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies?
The incidence of benign prostatic hyperplasia (BPH) is gradually on the increase. While conventional drugs such as the α1-adrenergic receptor …
Article scientifique
Inhibition of VEGF and Angiopoietin-2 to Reduce Brain Metastases of Breast Cancer Burden
For metastases in the central nervous system, angiogenesis enhances metastatic potential and promotes progression. Primary factors which drive vessel growth …
Article scientifique
Scaffold Diversity of Fungal Metabolites
Many drug discovery projects rely on commercial compounds to discover active leads. However, current commercial libraries, with mostly synthetic compounds, …
Article scientifique
Dexamethasone Pretreatment Alleviates Isoniazid/Lipopolysaccharide Hepatotoxicity: Inhibition of Inflammatory and Oxidative Stress
Isoniazid (INH) remains a cornerstone key constitute of the current tuberculosis management strategy, but its hepatotoxic potentiality remains a significant …