67 publication(s) trouvée(s)
Article scientifique
Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts of Lannea edulis in Alloxan-Induced Diabetic Rats
Lannea edulis (Sond.) Engl. commonly known as wild grape is used traditionally for the treatment of diabetes. It is only …
Article scientifique
Measuring Health-Related Quality of Life in Tuberous Sclerosis Complex – Psychometric Evaluation of Three Instruments in Individuals With Refractory Epilepsy
Tuberous Sclerosis Complex (TSC) is a rare genetic disease associated with significant disease burden and considerable impact on health-related quality …
Article scientifique
Pharmacological Action of a Pregnane Glycoside, Russelioside B, in Dietary Obese Rats: Impact on Weight Gain and Energy Expenditure
Background and purpose: Russelioside B (RB) is a pregnane glycoside obtained from Caralluma quadrangula; a herb with antidiabetic, anti-inflammatory and …
Article scientifique
Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus
Phyllanthus muellerianus (Family Euphorbiaceae), is a shrub which is widely distributed in West Africa and employed traditionally as a wound …
Article scientifique
Appropriateness of Cotrimoxazole Prophylactic Therapy Among HIV/AIDS Patients in Public Hospitals in Eastern Ethiopia: A Retrospective Evaluation of Clinical Practice
Background: Cotrimoxazole preventive therapy (CPT) is a feasible, cost-effective, and safe way of using cotrimoxazole intervention to reduce HIV/AIDS related …
Article scientifique
Toxic Effects of Trichloroethylene on Rat Neuroprogenitor Cells
. The current work aims to investigate the neurotoxic effects of a lower concentration of TCE on the same system. …
Article scientifique
Novel Trajectories of Bromocriptine Antidiabetic Action: Leptin-IL-6/ JAK2/p-STAT3/SOCS3, p-IR/p-AKT/GLUT4, PPAR-γ/Adiponectin, Nrf2/PARP-1, and GLP-1
Bromocriptine (BC), a sympatholytic dopaminergic D2 receptor agonist, has been comprehensively used in clinic to treat Parkinson's disease (PD) and …
Article scientifique
Anxiolytic and Antiepileptic Properties of the Aqueous Extract of Cissus quadrangularis (Vitaceae) in Mice Pilocarpine Model of Epilepsy
Cissus quadrangularis (C. quadrangularis) is a plant of the vitaceae family known for its anticonvulsant effects in traditional medicine. The …
Article scientifique
RETRACTED: Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models
Syzygium aqueumis widely used in folk medicine. A polyphenol-rich extract from its leaves demonstrated a plethora of substantial pharmacological properties. …
Article scientifique
Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model
Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. …
Article scientifique
Biological Activities of Heteropyxis natalensis Against Micro-Organisms Involved in Oral Infections
The use of complementary and alternative medicine from plants in South Africa, as in the rest of the world, continues …
Article scientifique
Fatty Acids Rich Extract From Clerodendrum volubile Suppresses Cell Migration; Abates Oxidative Stress; and Regulates Cell Cycle Progression in Glioblastoma Multiforme (U87 MG) Cells
Glioblastoma multiform (GBM) is a malignant primary type of brain cancer with high proliferation and metastasis rates due to involvement …
Article scientifique
Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis
Pristimerin (Pris) is bioactive natural quinonoid triterpene that has anti-inflammatory and anti-cancer activities. Meanwhile, its effect against hepatitis needs to …
Article scientifique
Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib
ACKNOWLEDGMENTS Work in SM’s lab is supported by AIRC, FIRC, CNR (Epigen), and Horizon 2020 grants. AKA has been awarded …
Article scientifique
S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression
Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate …
Article scientifique
Association between Health-Related Quality of Life and Medication Adherence in Pulmonary Tuberculosis in South Africa
Background: Health-related quality of life (HRQOL) and adherence to treatment are two often inter-related concepts that have implications for patient …
Article scientifique
Potentiation of Morphine-Induced Antinociception by Propranolol: The Involvement of Dopamine and GABA Systems
Tolerance to the analgesic effect of morphine is a major clinical problem which can be managed by co-administration of another …
Article scientifique
If Channel as an Emerging Therapeutic Target for Cardiovascular Diseases: A Review of Current Evidence and Controversies
In 2015, non-communicable diseases accounted for 39.5 million (70%) of the total 56.4 million deaths that occurred globally, of which …
Article scientifique
Nootropic and Neuroprotective Effects of Dichrocephala integrifolia on Scopolamine Mouse Model of Alzheimer’s Disease
Alzheimer’s disease the most common form of dementia in the elderly is a neurodegenerative disease that affects 44 millions of …
Article scientifique
Adapting Pharmacoeconomics to Shape Efficient Health Systems en Route to UHC – Lessons from Two Continents
Pharmacoeconomics is receiving increasing attention globally as a set of tools ensuring efficient use of resources in health systems, albeit …