Accès ouvert

RETRACTED: Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models

Article scientifique 2018 Anglais

Résumé

Syzygium aqueumis widely used in folk medicine. A polyphenol-rich extract from its leaves demonstrated a plethora of substantial pharmacological properties. The extract showed solid antioxidant propertiesin vitroand protected human keratinocytes (HaCaT cells) against UVA damage. The extract also reduced the elevated levels of ALT, AST, total bilirubin (TB), total cholesterol (TC) and triglycerides (TG) in rats with acute CCl4intoxication. In addition to reducing the high MDA level, the extract noticeably restored GSH and SOD to the normal control levels in liver tissue homogenates and counteracted the deleterious histopathologic changes in liver after CCl4injection. Additionally, the extract exhibited promising anti-inflammatory activitiesin vitrowhere it inhibited LOX, COX-1, and COX-2 with a higher COX-2 selectivity than that of indomethacin and diclofenac and reduced the extent of lysis of erythrocytes upon incubation with hypotonic buffer solution.S. aqueumextract also markedly reduced leukocyte numbers with similar activities to diclofenac in rats challenged with carrageenan. Additionally, administration of the extract abolished writhes induced by acetic acid in mice and prolonged the response latency in hot plate test. Meanwhile, the identified polyphenolics from the extract showed a certain affinity for the active pockets of 5-lipoxygenase (5-LOX), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) explaining the observed anti-inflammatory activities. Finally, 87 secondary metabolites (mostly phenolics) were tentatively identified in the extract based on LC-MS/MS analyses.Syzygium aqueumdisplays good protection against oxidative stress, free radicals, and could be a good candidate for treating oxidative stress related diseases.

Citer ce document

Sobeh, M., Mahmoud, M., Petruk, G., Rezq, S., Ashour, M., Youssef, F., El‐Shazly, A., Monti, D., Abdel‐Naim, A., Wink, M. (2018). RETRACTED: Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models. https://doi.org/10.3389/fphar.2018.00566

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Mansour Sobeh Mona F. Mahmoud Ganna Petruk Samar Rezq Mohamed L. Ashour Fadia S. Youssef Assem M. El‐Shazly Daria Maria Monti Ashraf B. Abdel‐Naim Michaël Wink

Statistiques

Consultations : 3

Téléchargements : 0