57 publication(s) trouvée(s)
Article scientifique
Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety
BACKGROUND: Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted …
Article scientifique
Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties
Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. …
Article scientifique
Selective synthesis of Fe3O4Au x Ag y nanomaterials and their potential applications in catalysis and nanomedicine
) has witnessed a growing interest in the scientific community as a potential material in various fields of application namely …
Article scientifique
Utility of 2-thioxo-pyrido[2,3-d]pyrimidinone in synthesis of pyridopyrimido[2,1-b][1,3,5]-thiadiazinones and pyridopyrimido[2,1-b][1,3]thiazinones as antimicrobial agents
Pyridopyrimidines are of current interest because of their extensive variety of biological and pharmacological activities. A series of pyrido[2′,3′:4,5]pyrimido[2,1-b][1,3,5]thiadiazinones was …
Article scientifique
QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity
BACKGROUND: ranging from 5.55 to 9 µM and from 4.66 to 8.22 µM, respectively, using genetic function algorithm for variable …
Article scientifique
Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents
BACKGROUND: The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant …
Article scientifique
Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety
BACKGROUND: A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a-t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate …
Article scientifique
Rapid simultaneous determination of indacaterol maleate and glycopyrronium bromide in inhaler capsules using a validated stability-indicating monolithic LC method
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. A combination of indacaterol maleate …
Article scientifique
Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation
Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). …
Article scientifique
Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra
Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been …
Article scientifique
Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
BACKGROUND: Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. RESULTS: H NMR and mass spectral data. …
Article scientifique
Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity
BACKGROUND: Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active …
Article scientifique
Natural product based composite for extraction of arsenic (III) from waste water
Natural based composites of hydroxyapatite/Gum Arabic designed for removal of toxic metal arsenic (III) from waste water were synthesized and …
Article scientifique
Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking
BACKGROUND: Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are …
Article scientifique
Highlighting mass spectrometric fragmentation differences and similarities between hydroxycinnamoyl-quinic acids and hydroxycinnamoyl-isocitric acids
BACKGROUND: Plants contain a myriad of metabolites which exhibit diverse biological activities. However, in-depth analyses of these natural products with …
Article scientifique
Non-destructive determination of ethanol levels in fermented alcoholic beverages using Fourier transform mid-infrared spectroscopy
BACKGROUND: Traditional fermented alcoholic beverages are indigenous to a particular area and are prepared by the local people using an …
Article scientifique
A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety
Thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. A novel series of thiazoles carrying 1,3,4-thiadiazole core were …
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