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Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

Article scientifique 2017 Anglais

Résumé

BACKGROUND: Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. RESULTS: H NMR and mass spectral data. All the synthesized compounds were tested for in vitro activities against two antitumor cell lines, human lung cancer and human hepatocellular carcinoma compared with the employed standard antitumor drug (cisplatin). CONCLUSIONS: All the newly synthesized compounds were evaluated for their anticancer activity against human lung cancer and human hepatocellular carcinoma cell lines using MTT assay. The results obtained exploring the high potency of six of the tested compounds compared with cisplatin. Graphical abstract Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents.

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Gomha, S., Edrees, M., Faty, R., Muhammad, Z., Mabkhot, Y. (2017). Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents. https://doi.org/10.1186/s13065-017-0266-4

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Auteur(s)

Sobhi M. Gomha Mastoura M. Edrees Rasha A. M. Faty Zeinab A. Muhammad Yahia N. Mabkhot

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