57 publication(s) trouvée(s)
Article scientifique
Experimental and theoretical study of donor-π-acceptor compounds based on malononitrile
A set of different donor-π-acceptor compounds having dicyanovinyl as the acceptor and aryl moieties as donors were synthesized by Knoevenagel …
Article scientifique
Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures
Design and synthesis of pyrazole-dimedone derivatives were described by one-pot multicomponent reaction as new antimicrobial agents. These new molecular framework …
Article scientifique
Synthesis, structural determination and antimicrobial evaluation of two novel CoII and ZnII halogenometallates as efficient catalysts for the acetalization reaction of aldehydes
BACKGROUND: Complexes of imidazole derivatives with transition metal ions have attracted much attention because of their biological and pharmacological activities, …
Article scientifique
Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods
Flutamide is a potential antineoplastic drug classified as an anti-androgen. It is a therapy for men with advanced prostate cancer, …
Article scientifique
Evaluation of water quality and human risk assessment due to heavy metals in groundwater around Muledane area of Vhembe District, Limpopo Province, South Africa
Groundwater is considered as good alternative to potable water because of its low turbidity and perceived low contamination. The study …
Article scientifique
Development of new analytical methods for the determination of caffeine content in aqueous solution of green coffee beans
BACKGROUND: This study was conducted to develop fast and cost effective methods for the determination of caffeine in green coffee …
Article scientifique
LC–MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate
Masitinib (MST) is a selective tyrosine kinase inhibitor. Validated liquid chromatography tandem mass spectrometric method (LC–MS/MS) was developed for the …
Article scientifique
Electrochemical behavior and in-vitro antimicrobial screening of some thienylazoaryls dyes
BACKGROUND: A series of recently reported phenolic azo dyes 7a-e were prepared by coupling the thienyl diazonium sulfate of 3-Amino-4H-benzo[f]thieno[3,4-c](2H)chromen-4-one …
Article scientifique
Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
BACKGROUND: Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities …
Article scientifique
Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether
BACKGROUND: 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. RESULTS: This study describes a green, efficient and quick …
Article scientifique
Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations
BACKGROUND: The combination between cetirizine (CET), phenylpropanolamine (PPA) and nimesulide (NMS) under trade name Nemeriv Cp tablet is prescribed for …
Article scientifique
Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives
The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as …
Article scientifique
Preparative HPLC for large scale isolation, and salting-out assisted liquid–liquid extraction based method for HPLC–DAD determination of khat (Catha edulis Forsk) alkaloids
Khat ( Catha edulis Forsk) is an evergreen shrub of the Celastraceae family. It is widely cultivated in Yemen and …
Article scientifique
Synthesis and anticancer activity of novel quinazolinone-based rhodanines
Rhodanines and quinazolinones have been reported to possess various pharmacological activities. A novel series of twenty quinazolinone-based rhodanines were synthesized …
Article scientifique
A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents
Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially …
Article scientifique
Novel pyridine-based Pd(II)-complex for efficient Suzuki coupling of aryl halides under microwaves irradiation in water
Suzuki C-C cross-coupling of aryl halides with aryl boronic acids using new phosphene-free palladium complexes as precatalysts was investigated. A …
Article scientifique
Erratum to: One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines
Article scientifique
Surface bound radicals, char yield and particulate size from the burning of tobacco cigarette
Tobacco smoke is a toxic gas-phase cocktail consisting of a broad range of organics, and free radical intermediates. The formation …
Article scientifique
Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate
BACKGROUND: The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological …
Article scientifique
One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines
Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines …