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Publications
4586 publication(s) trouvée(s)
Article scientifique
A RNAi-based therapeutic proof of concept targets salmonid whirling disease in vivo
Myxobolus cerebralis is a cnidarian-myxozoan parasite that causes salmonid whirling disease. M. cerebralis alternates between two hosts: (1) a vertebrate …
Article scientifique
Antiviral evaluation of an Hsp90 inhibitor, gedunin, against dengue virus
Purpose: To evaluate the antiviral potential of a tetranortriterpenoid, gedunin, against dengue virus (DENV) replication by targeting the host chaperone, …
Article scientifique
IpiRId: Integrative approach for piRNA prediction using genomic and epigenomic data
Many computational tools have been proposed during the two last decades for predicting piRNAs, which are molecules with important role …
Article scientifique
A novel constructed SPT15 mutagenesis library of Saccharomyces cerevisiae by using gTME technique for enhanced ethanol production
During the last few years, the global transcription machinery engineering (gTME) technique has gained more attention as an effective approach …
Article scientifique
Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats
BACKGROUND: Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract …
Article scientifique
Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis
More than two decades after cloning the cystic fibrosis transmembrane regulator (CFTR) gene, the defective gene in cystic fibrosis (CF), …
Article scientifique
Surveillance of surgical site infections by Pseudomonas aeruginosa and strain characterization in Tanzanian hospitals does not provide proof for a role of hospital water plumbing systems in transmission
The role of hospital water systems in the development of Pseudomonas aeruginosa ( P. aeruginosa ) surgical site infections (SSIs) …
Article scientifique
Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues
BACKGROUND: Nicotinic acetylcholine receptors (nAChRs) play an important role in cellular physiology and human nicotine dependence, and are closely associated …
Article scientifique
The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas
BACKGROUND: The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell …
Article scientifique
Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae)
BACKGROUND: Tuberculosis is counted amongst the most infectious and lethal illnesses worldwide and remains one of the major threats to …
Article scientifique
Selection and Validation of Appropriate Reference Genes for qRT-PCR Analysis in Isatis indigotica Fort.
Due to its sensitivity and specificity, real-time quantitative PCR (qRT-PCR) is a popular technique for investigating gene expression levels in …
Article scientifique
Expression of the Aeluropus littoralis AlSAP Gene Enhances Rice Yield under Field Drought at the Reproductive Stage
under the control of different promoters. Three independent field trials were conducted, with drought imposed at the reproductive stage. In …
Article scientifique
Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation
The mechanisms behind the transmission of chromosomal aberrations (CA) remain unclear, despite a large body of work and major technological …
Article scientifique
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
BACKGROUND: SIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital …
Article scientifique
RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation
Neural activity is crucial for the refinement of neuronal connections during development, but the contribution of synaptic release mechanisms is …
Article scientifique
High frequency of the recurrent c.1310_1313delAAGA BRCA2 mutation in the North-East of Morocco and implication for hereditary breast–ovarian cancer prevention and control
BACKGROUND: To date, a limited number of BRCA1/2 germline mutations have been reported in hereditary breast and/or ovarian cancer in …
Article scientifique
Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis
BACKGROUND: To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in …
Article scientifique
Minimal genetic change in Vibrio cholerae in Mozambique over time: Multilocus variable number tandem repeat analysis and whole genome sequencing
Although cholera is a major public health concern in Mozambique, its transmission patterns remain unknown. We surveyed the genetic relatedness …
Article scientifique
Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8
It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level …
Article scientifique
Neighborhood-targeted and case-triggered use of a single dose of oral cholera vaccine in an urban setting: Feasibility and vaccine coverage
INTRODUCTION: In June 2015, a cholera outbreak was declared in Juba, South Sudan. In addition to standard outbreak control measures, …