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Biologie synthétique
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Publications
4280 publication(s) trouvée(s)
Article scientifique
Bivariate longitudinal data analysis: a case of hypertensive patients at Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia
OBJECTIVE: Longitudinal data are often collected to study the evolution of biomedical markers. The study of the joint evolution of …
Article scientifique
Effects of interactions between common genetic variants and smoking on colorectal cancer
Although genome-wide association studies (GWAS) have identified variants in approximately 40 susceptibility loci for colorectal cancer (CRC), there are few …
Article scientifique
Using standard keywords in publications to facilitate updates of new fungal taxonomic names
Abstract The combination of manual curation and the reliance on updates from submitters to the public sequence databases is currently …
Article scientifique
Intragenic recombination between two non-functional semi-dwarf 1 alleles produced a functional SD1 allele in a tall recombinant inbred line in rice
Intragenic recombination is one of the most important sources of genetic variability. In our previous study, RI92 a tall line …
Article scientifique
Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways
BACKGROUND: We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan and irinotecan in gastric cancer …
Article scientifique
Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy
A metabolome-wide genome-wide association study (mGWAS) aims to discover the effects of genetic variants on metabolome phenotypes. Most mGWASes use …
Article scientifique
Developing data interoperability using standards: A wheat community use case
In this article, we present a joint effort of the wheat research community, along with data and ontology experts, to …
Article scientifique
Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin
Fibronectin is an extracellular matrix glycoprotein with key roles in cell adhesion and migration. Hsp90 binds directly to fibronectin and …
Article scientifique
Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis
Spermatogenesis consists of a series of highly regulated processes that include mitotic proliferation, meiosis and cellular remodeling. Although alterations in …
Article scientifique
The common enteric bacterial pathogens and their antimicrobial susceptibility pattern among HIV-infected individuals attending the antiretroviral therapy clinic of Hawassa university hospital, southern Ethiopia
Background: The frequent occurrence of bacterial gastroenteritis among HIV-infected individuals together with increased antimicrobial drug resistance pose a significant public …
Article scientifique
Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell
BACKGROUND: The nuclear epigenetic integrator UHRF1 is known to play a key role with DNMT1 in maintaining the DNA methylation …
Article scientifique
Characterization of Mycosphaerellaceae species associated with citrus greasy spot in Panama and Spain
Greasy spot of citrus, caused by Zasmidium citri-griseum (= Mycosphaerella citri), is widely distributed in the Caribbean Basin, inducing leaf …
Article scientifique
The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
Abstract Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular …
Article scientifique
Tissue-Specific Expression of DNA Methyltransferases Involved in Early-Life Nutritional Stress of Chicken, Gallus gallus
DNA methylation was reported as a possible stress-adaptation mechanism involved in the transcriptional regulation of stress responsive genes. Limited data …
Article scientifique
In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine
Discovery of novel gametocytocidal molecules is a major pharmacological strategy in the elimination and eradication of malaria. The high patronage …
Article scientifique
Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential
The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells …
Article scientifique
Large-scale production of a thermostable Rhodothermus marinus cellulase by heterologous secretion from Streptomyces lividans
BACKGROUND: The gene encoding a thermostable cellulase of family 12 was previously isolated from a Rhodothermus marinus through functional screening. …
Article scientifique
LC–MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate
Masitinib (MST) is a selective tyrosine kinase inhibitor. Validated liquid chromatography tandem mass spectrometric method (LC–MS/MS) was developed for the …
Article scientifique
Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with deficits in cognition and synaptic plasticity. While accumulation of amyloid β …
Article scientifique
Genomic footprints of dryland stress adaptation in Egyptian fat-tail sheep and their divergence from East African and western Asia cohorts
African indigenous sheep are classified as fat-tail, thin-tail and fat-rump hair sheep. The fat-tail are well adapted to dryland environments, …