6057 publication(s) trouvée(s)
Article scientifique
Correction: Prognostic power of global 2D strain according to left ventricular ejection fraction in patients with ST elevation myocardial infarction
[This corrects the article DOI: 10.1371/journal.pone.0174160.].
Article scientifique
Scaffold dependent histone deacetylase (HDAC) inhibitor induced re-equilibration of the subcellular localization and post-translational modification state of class I HDACs
The mechanism of action of histone deacetylase inhibitors (HDACi) is mainly attributed to the inhibition of the deacetylase catalytic activity …
Article scientifique
Kinetics of antibodies against pneumococcal proteins and their relationship to nasopharyngeal carriage in the first two months of life
INTRODUCTION: The currently used Streptococcus pneumoniae vaccines have had a significant impact on the pneumococcal diseases caused by the serotypes …
Article scientifique
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses …
Article scientifique
Predicting local malaria exposure using a Lasso-based two-level cross validation algorithm
Recent studies have highlighted the importance of local environmental factors to determine the fine-scale heterogeneity of malaria transmission and exposure …
Article scientifique
Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules
Human babesiosis is caused by the apicomplexan parasite Babesia microti, which is of major public health concern in the United …
Article scientifique
The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent
Multiple myeloma (MM), a malignancy of the bone marrow, is characterized by a pathological increase in antibody-producing plasma cells and …
Article scientifique
Reduction of in utero lead exposures in South African populations: Positive impact of unleaded petrol
BACKGROUND: Prenatal exposure to lead (Pb) has been shown to have negative and irreversible health impacts on foetal and early …
Article scientifique
Buccal dental-microwear and dietary ecology in a free-ranging population of mandrills (Mandrillus sphinx) from southern Gabon
Analyses of dental micro- and macro-wear offer valuable information about dietary adaptations. The buccal surface of the teeth does not …
Article scientifique
Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children
BACKGROUND: The antiretroviral drug nevirapine and the antimalarial artemisinin-based combination therapy artemether-lumefantrine are commonly co-administered to treat malaria in the …
Article scientifique
Role of p16 testing in cervical cancer screening among HIV-infected women
BACKGROUND: p16 immunohistochemistry is used to evaluate for HPV-associated cervical intraepithelial neoplasia. The diagnostic performance of p16 in HIV infection …
Article scientifique
Transitioning couple’s voluntary HIV counseling and testing (CVCT) from stand-alone weekend services into routine antenatal and VCT services in government clinics in Zambia’s two largest cities
INTRODUCTION: Most HIV infections in Africa are acquired by married/cohabiting adults and WHO recommends couple's voluntary HIV counseling and testing …
Article scientifique
Perceived needs of health tutors in rural and urban health training institutions in Ghana: Implications for health sector staff internal migration control
BACKGROUND: The population of Ghana is increasingly becoming urbanized with about 70% of the estimated 27 million people living in …
Article scientifique
Penile coital injuries in men decline after circumcision: Results from a prospective study of recently circumcised and uncircumcised men in western Kenya
BACKGROUND: Penile coital injuries are one of the suggested mechanisms behind the increased risk of HIV among uncircumcised men. We …
Article scientifique
Predictors of voluntary medical male circumcision prevalence among men aged 25-39 years in Nyanza region, Kenya: Results from the baseline survey of the TASCO study
INTRODUCTION: Uptake of voluntary medical male circumcision (VMMC) as an intervention for prevention of HIV acquisition has been low among …
Article scientifique
Half of rifampicin-resistant Mycobacterium tuberculosis complex isolated from tuberculosis patients in Sub-Saharan Africa have concomitant resistance to pyrazinamide
BACKGROUND: Besides inclusion in 1st line regimens against tuberculosis (TB), pyrazinamide (PZA) is used in 2nd line anti-TB regimens, including …
Article scientifique
Corneal transplantation at Tenwek Hospital, Kenya, East Africa: Analysis of outcomes and associated patient socioeconomic characteristics
PURPOSE: To review the graft survival rate, visual outcomes, and patient demographics of primary penetrating keratoplasty performed at Tenwek Hospital, …
Article scientifique
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform
Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including …
Article scientifique
Tuberculosis mortality and the male survival deficit in rural South Africa: An observational community cohort study
BACKGROUND: Women live on average five years longer than men, and the sex difference in longevity is typically lower in …
Article scientifique
Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study
BACKGROUND: The emergence, accumulation and spread of HIV-1 drug resistance strains in Africa could compromise the effectiveness of HIV treatment …