57 publication(s) trouvée(s)
Article scientifique
Determination of antioxidant and antimicrobial activities of the extracts of aerial parts of Portulaca quadrifida
BACKGROUND: The extracts from the aerial parts of Portulaca quadrifida have been reported to show the total flavonoid content, antioxidant …
Article scientifique
Ligand exchange method for determination of mole ratios of relatively weak metal complexes: a comparative study
Ligand exchange method is introduced as an alternative to Job’s and mole ratio methods for studying the stoichiometry of relatively …
Article scientifique
Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives
BACKGROUND: A novel series of 1,2,3-triazole derivatives containing 1,4-benzothiazin-3-one ring (7a-9a, 7b-9b), (10a-12a, 10b-12b) and (13-15) were synthesized by 1,3-dipolar …
Article scientifique
Synthesis, crystal structure, DFT studies and biological activity of (Z)-3-(3-bromophenyl)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxyprop-2-en-1-one
BACKGROUND: Nowadays, is emerging a new generation of highly promising inhibitors bearing the β-ketoenol functionality. The present work relates to …
Article scientifique
Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
Nitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers. A series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates …
Article scientifique
Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS
Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the …
Article scientifique
Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes
BACKGROUND: Resistance of bacteria and fungi to antibiotics is one of the biggest problems that faces public health. The present …
Article scientifique
Free radicals and ultrafine particulate emissions from the co-pyrolysis of Croton megalocarpus biodiesel and fossil diesel
BACKGROUND: The atmosphere has become a major transport corridor for free radicals and particulate matter from combustion events. The motivation …
Article scientifique
Removal of malachite green from aqueous solution using pulverized teak leaf litter: equilibrium, kinetic and thermodynamic studies
The removal of malachite green (MG) from aqueous solution using teak leaf litter powder (TLLP) was investigated. The process was …
Article scientifique
Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques
Paracetamol (PAR), Pseudoephedrine hydrochloride (PSE) and cetirizine dihydrochloride (CET) is a ternary mixture that composes tablets which are popular for …
Article scientifique
A facile synthesis, and antimicrobial and anticancer activities of some pyridines, thioamides, thiazole, urea, quinazoline, β-naphthyl carbamate, and pyrano[2,3-d]thiazole derivatives
Chalcones have a place with the flavonoid family and show a few very important pharmacological activities. They can used as …
Article scientifique
Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry
Masitinib (MST) is an orally administered drug that targets mast cells and macrophages, important cells for immunity, by inhibiting a …
Article scientifique
Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study
To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human …
Article scientifique
Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent
Described a series of main target compounds pyrimido[5,4-e][1,2,4]triazines is obtained via condensation of 6-hydrazinyluracil with different aromatic aldehydes to give …
Article scientifique
Determination of antioxidant and antimicrobial activities of leaf extracts of Otostegia integrifolia
BACKGROUND: The extracts from the leaves of Otostegia integrifolia have been reported to show phytochemical analysis, total flavonoid content, antioxidant …
Article scientifique
Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents
BACKGROUND: The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs …
Article scientifique
Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties
A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole, triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl)ethylideneamino]-2-thioxoimidazolidin-4-one 1 …
Article scientifique
Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity
BACKGROUND AND OBJECTIVE: A series of thiazolopyrimidine derivatives have been synthesized via multicomponent reaction and tested for biological activities. This …
Article scientifique
New fluorescence spectroscopic method for the simultaneous determination of alkaloids in aqueous extract of green coffee beans
BACKGROUND: There is no fluorescence spectroscopic method for the determination of trigonelline and theobromine in green coffee beans. Therefore, the …
Article scientifique
QSAR study and rustic ligand-based virtual screening in a search for aminooxadiazole derivatives as PIM1 inhibitors
BACKGROUND: in nM). The present study was performed using Genetic Algorithm method of variable selection (GFA), multiple linear regression analysis …
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