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Publications
4601 publication(s) trouvée(s)
Article scientifique
COMODI: an ontology to characterise differences in versions of computational models in biology
BACKGROUND: Open model repositories provide ready-to-reuse computational models of biological systems. Models within those repositories evolve over time, leading to …
Article scientifique
Efficient In Vitro and In Vivo Activity of Glyco-Engineered Plant-Produced Rabies Monoclonal Antibodies E559 and 62-71-3
Rabies is a neglected zoonotic disease that has no effective treatment after onset of illness. However the disease can be …
Article scientifique
Multivariate characterization of morphological traits in West African cattle sires
Abstract. A total of 183 adult sires belonging to nine West African cattle breeds sampled in 67 villages of Mali, …
Article scientifique
Genotype-phenotype analysis of von Hippel-Lindau syndrome in Korean families: HIF-α binding site missense mutations elevate age-specific risk for CNS hemangioblastoma
BACKGROUND: von Hippel-Lindau (VHL) disease is a rare hereditary tumor syndrome caused by VHL gene mutations that is characterized by …
Article scientifique
Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma
BACKGROUND: The mitochondrial GTPase mitofusin-2 (MFN2) gene encodes a mitochondrial membrane protein that can induce apoptosis of hepatocellular carcinoma (HCC) …
Article scientifique
Activation of the JNK-c-Jun pathway in response to irradiation facilitates Fas ligand secretion in hepatoma cells and increases hepatocyte injury
BACKGROUND: It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced …
Article scientifique
Allovahlkampfia spelaea Causing Keratitis in Humans
BACKGROUND: Free-living amoebae are present worldwide. They can survive in different environment causing human diseases in some instances. Acanthamoeba sp. …
Article scientifique
Effect of Cryopreservation and Post-Cryopreservation Somatic Embryogenesis on the Epigenetic Fidelity of Cocoa (Theobroma cacao L.)
UNLABELLED: While cocoa plants regenerated from cryopreserved somatic embryos can demonstrate high levels of phenotypic variability, little is known about …
Article scientifique
Expression patterns, mutation detection and RNA interference of Rhopalosiphum padi voltage-gated sodium channel genes
The voltage-gated sodium channel (VGSC) is the target of sodium-channel-blocking insecticides. Traditionally, animals were thought to have only one VGSC …
Article scientifique
Prevalence of pathogenic free-living amoeba and other protozoa in natural and communal piped tap water from Queen Elizabeth protected area, Uganda
BACKGROUND: Pathogenic water dwelling protozoa such as Acanthamoeba spp., Hartmannella spp., Naegleria spp., Cryptosporidium spp. and Giardia spp. are often …
Article scientifique
Structural and Catalytic Characterization of a Fungal Baeyer-Villiger Monooxygenase
Baeyer-Villiger monooxygenases (BVMOs) are biocatalysts that convert ketones to esters. Due to their high regio-, stereo- and enantioselectivity and ability …
Article scientifique
A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
The fragile X-related disorders result from expansion of a CGG/CCG microsatellite in the 5' UTR of the FMR1 gene. We …
Article scientifique
RNAi-mediated knockdown of the voltage gated sodium ion channel TcNav causes mortality in Tribolium castaneum
The voltage-gated sodium ion channel (VGSC) belongs to the largest superfamily of ion channels. Since VGSCs play key roles in …
Article scientifique
Surveillance of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Dairy Cattle Farms in the Nile Delta, Egypt
INTRODUCTION: Industrial livestock farming is a possible source of multi-resistant Gram-negative bacteria, including producers of extended spectrum beta-lactamases (ESBLs) conferring …
Article scientifique
Identification of SNP and SSR Markers in Finger Millet Using Next Generation Sequencing Technologies
Finger millet is an important cereal crop in eastern Africa and southern India with excellent grain storage quality and unique …
Article scientifique
In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides …
Article scientifique
Transitions in a genetic transcriptional regulatory system under Lévy motion
Based on a stochastic differential equation model for a single genetic regulatory system, we examine the dynamical effects of noisy …
Article scientifique
Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas
Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single …
Article scientifique
Antimicrobial and anti-Quorum Sensing activities of selected medicinal plants of Ethiopia: Implication for development of potent antimicrobial agents
BACKGROUND: Traditional medicinal plants have been used as an alternative medicine in many parts of the world, including Ethiopia. There …
Article scientifique
Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV
The accumulation of lipid droplets (LD) is frequently observed in hepatitis C virus (HCV) infection and represents an important risk …