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Publications
4601 publication(s) trouvée(s)
Article scientifique
Cholera in Cameroon, 2000-2012: Spatial and Temporal Analysis at the Operational (Health District) and Sub Climate Levels
INTRODUCTION: Recurrent cholera outbreaks have been reported in Cameroon since 1971. However, case fatality ratios remain high, and we do …
Article scientifique
Bacterially-Associated Transcriptional Remodelling in a Distinct Genomic Subtype of Colorectal Cancer Provides a Plausible Molecular Basis for Disease Development
The relevance of specific microbial colonisation to colorectal cancer (CRC) disease pathogenesis is increasingly recognised, but our understanding of possible …
Article scientifique
Insight into the genetic composition of South African Sanga cattle using SNP data from cattle breeds worldwide
BACKGROUND: Understanding the history of cattle breeds is important because it provides the basis for developing appropriate selection and breed …
Article scientifique
Extended-Spectrum beta (β)-Lactamases and Antibiogram in Enterobacteriaceae from Clinical and Drinking Water Sources from Bahir Dar City, Ethiopia
BACKGROUND: The spread of Extended-Spectrum beta (β)-Lactamases (ESBL)-producing Enterobacteriaceae has become a serious global problem. ESBL-producing Enterobacteriaceae vary based on …
Article scientifique
PRIMO: An Interactive Homology Modeling Pipeline
The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These …
Article scientifique
Association mapping of resistance to rice blast in upland field conditions
BACKGROUND: Rice blast is one of the most damaging disease of rice. The use of resistant cultivars is the only …
Article scientifique
Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women
BACKGROUND: Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations …
Article scientifique
Genetic elements associated with antimicrobial resistance among avian pathogenic Escherichia coli
Avian-pathogenic Escherichia coli (APEC) are pathogenic strains of E. coli that are responsible for one of the most predominant bacterial …
Article scientifique
Comparison of antibiotic resistant Escherichia coli obtained from drinking water sources in northern Tanzania: a cross-sectional study
Antimicrobial resistance (AMR) is a growing and significant threat to public health on a global scale. Escherichia coli comprises Gram-negative, …
Article scientifique
Getting miRNA Therapeutics into the Target Cells for Neurodegenerative Diseases: A Mini-Review
MiRNAs play important roles in modulating gene expression in varying cellular processes and disease pathogenesis, including neurodegenerative diseases. Several miRNAs …
Article scientifique
A Comparative Metabolomics Approach Reveals Early Biomarkers for Metabolic Response to Acute Myocardial Infarction
Abstract Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Serum metabolite profiling of ST-elevation …
Article scientifique
The correlation between antimutagenic activity and total phenolic content of extracts of 31 plant species with high antioxidant activity
BACKGROUND: Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. There is increasing …
Article scientifique
Understanding rare and common diseases in the context of human evolution
The wealth of available genetic information is allowing the reconstruction of human demographic and adaptive history. Demography and purifying selection …
Article scientifique
An Enrichment of CRISPR and Other Defense-Related Features in Marine Sponge-Associated Microbial Metagenomes
Many marine sponges are populated by dense and taxonomically diverse microbial consortia. We employed a metagenomics approach to unravel the …
Article scientifique
Evaluation of Machine Learning and Rules-Based Approaches for Predicting Antimicrobial Resistance Profiles in Gram-negative Bacilli from Whole Genome Sequence Data
The time-to-result for culture-based microorganism recovery and phenotypic antimicrobial susceptibility testing necessitate initial use of empiric (frequently broad-spectrum) antimicrobial therapy. …
Article scientifique
Measures for interoperability of phenotypic data: minimum information requirements and formatting
BACKGROUND: Plant phenotypic data shrouds a wealth of information which, when accurately analysed and linked to other data types, brings …
Article scientifique
Circulating exosomes from patients with systemic lupus erythematosus induce a proinflammatory immune response
BACKGROUND: Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute …
Article scientifique
Beneficial Roles of Melatonin on Redox Regulation of Photosynthetic Electron Transport and Synthesis of D1 Protein in Tomato Seedlings under Salt Stress
Melatonin is important in the protection of plants suffering various forms of abiotic stress. The molecular mechanisms underlying the melatonin-mediated …
Article scientifique
Characterizing the morbid genome of ciliopathies
BACKGROUND: Ciliopathies are clinically diverse disorders of the primary cilium. Remarkable progress has been made in understanding the molecular basis …
Article scientifique
Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease
Abstract Intestinal microbial dysbiosis is associated with Crohn’s disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that …