Sciences de la vie et biotechnologies

Article scientifique

Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including …

2017 Open Access

Article scientifique

New species of Auritella (Inocybaceae) from Cameroon, with a worldwide key to the known species

Two new species in the genus Auritella (Inocybaceae) are described as new from tropical rainforest in Cameroon. Descriptions, photographs, line …

2017 Open Access

Article scientifique

A highly efficient ligation-independent cloning system for CRISPR/Cas9 based genome editing in plants

Most current methods for constructing guide RNAs (gRNA) for the CRISPR/Cas9 genome editing system, depend on traditional cloning using specific …

2017 Open Access

Article scientifique

Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children’s health in India and Sub-Saharan Africa

BACKGROUND: Animal studies have shown that nutritional exposures during pregnancy can modify epigenetic marks regulating fetal development and susceptibility to …

2017 Open Access

Article scientifique

Dimensionality reduction and class prediction algorithm with application to microarray Big Data

The recent technology development in the concern of microarray experiments has provided many new potentialities in terms of simultaneous measurement. …

2017 Open Access

Article scientifique

Multi-site cholera surveillance within the African Cholera Surveillance Network shows endemicity in Mozambique, 2011–2015

BACKGROUND: Mozambique suffers recurrent annual cholera outbreaks especially during the rainy season between October to March. The African Cholera Surveillance …

2017 Open Access

Article scientifique

Asymmetric BMP4 signalling improves the realism of kidney organoids

We present a strategy for increasing the anatomical realism of organoids by applying asymmetric cues to mimic spatial information that …

2017 Open Access

Article scientifique

Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma

BACKGROUND: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that …

2017 Open Access

Article scientifique

Correlates of multi-drug non-susceptibility in enteric bacteria isolated from Kenyan children with acute diarrhea

BACKGROUND: Reduced antimicrobial susceptibility threatens treatment efficacy in sub-Saharan Africa, where data on the burden and correlates of antibiotic resistance …

2017 Open Access

Article scientifique

Epidemiological link of a major cholera outbreak in Greater Accra region of Ghana, 2014

BACKGROUND: Cholera remains an important public health challenge globally. Several pandemics have occurred in different parts of the world and …

2017 Open Access

Article scientifique

Extended spectrum and metalo beta-lactamase producing airborne Pseudomonas aeruginosa and Acinetobacter baumanii in restricted settings of a referral hospital: a neglected condition

Frequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment. The …

2017 Open Access

Article scientifique

Whole genome population genetics analysis of Sudanese goats identifies regions harboring genes associated with major traits

Sudan is endowed with a variety of indigenous goat breeds which are used for meat and milk production and which …

2017 Open Access

Article scientifique

Phenotypic and genotypic characterization of antimicrobial susceptibility of avian pathogenic Escherichia coli isolated from broiler chickens

AIM: isolated from diseased and freshly dead broilers. MATERIALS AND METHODS: ). RESULTS: had the lowest prevalence (23%). CONCLUSION: The …

2017 Open Access

Article scientifique

Bacillus Cereus isolation and load from raw cow milk sold in Markets of Haramaya District, eastern Ethiopia

Bacillus cereus is a spore-forming bacterium that is widely distributed in the environment and can be detected in a variety …

2017 Open Access

Article scientifique

Genetic variation and population structure of maize inbred lines adapted to the mid-altitude sub-humid maize agro-ecology of Ethiopia using single nucleotide polymorphic (SNP) markers

BACKGROUND: Molecular characterization is important for efficient utilization of germplasm and development of improved varieties. In the present study, we …

2017 Open Access

Article scientifique

Designing a course model for distance-based online bioinformatics training in Africa: The H3ABioNet experience

Africa is not unique in its need for basic bioinformatics training for individuals from a diverse range of academic backgrounds. …

2017 Open Access

Article scientifique

Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

Hepatocellular carcinoma harbors numerous genomic and epigenomic aberrations of DNA copy numbers and DNA methylation. Transcriptomic deregulation by these aberrations …

2017 Open Access

Article scientifique

ارزیابی تنوع ژنتیکی ژنوتیپهای گل رز (Rosa hybrid) با استفاده از نشانگرهای CDDP و RAPD

Identification of genetic diversity and classification of genetic resources (germplasm) are of important and essential activities in breeding and management …

2017 Open Access

Article scientifique

Effectiveness of model-based clustering in analyzing Plasmodium falciparum RNA-seq time-course data

Background: The genomics and microarray technology played tremendous roles in the amount of biologically useful information on gene expression of …

2017 Open Access

Article scientifique

Evaluation of production and reproduction of three South African Angora goat CYP17 genotypes

Two CYP17 genes, located on different loci and expressing enzymes with significantly different activities, have been identified in the South …

2017 Open Access