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4149 publication(s)
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Publications
4155 publication(s) trouvée(s)
Article scientifique
Dried Blood Spots for Measuring Vibrio cholerae-specific Immune Responses
BACKGROUND: Vibrio cholerae causes over 2 million cases of cholera and 90,000 deaths each year. Serosurveillance can be a useful …
Article scientifique
Genomics research in Africa and its impact on global health: insights from African researchers
Africa may be heading for an era of genomics medicine. There are also expectations that genomics may play a role …
Article scientifique
High prevalence of ESBL-Producing E. coli in private and shared latrines in an informal urban settlement in Dar es Salaam, Tanzania
Abstract Background Data about the burden of extended-spectrum beta-lactamase (ESBL)-producing microorganisms in Africa are limited. Our study aimed to estimate …
Article scientifique
Molecular characterization of resistance mechanisms in Pseudomonas aeruginosa isolates resistant to carbapenems
INTRODUCTION: Emergence of carbapenem resistance in Pseudomonas aeruginosa increases the therapeutic dilemma. In this study, we investigated various mechanisms involved …
Article scientifique
GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10
Glycogen synthase kinase 3β (GSK3β) is a ubiquitously expressed serine/threonine kinase involved in the regulation of various cellular functions, such …
Article scientifique
The emergence of long non-coding RNAs in hepatocellular carcinoma: an update
Hepatocellular carcinoma (HCC) accounting for roughly 90% of all primary liver neoplasms is the sixth most frequent neoplasm and the …
Article scientifique
Genetics of breast cancer in African populations: a literature review
Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide. The present …
Article scientifique
AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD). …
Article scientifique
Speciation of common Gram-negative pathogens using a highly multiplexed high resolution melt curve assay
The identification of the bacterial species responsible for an infection remains an important step for the selection of antimicrobial therapy. …
Article scientifique
Ecological plasticity in the gastrointestinal microbiomes of Ethiopian Chlorocebus monkeys
Human activities can cause habitat degradation that may alter the types and quality of available food resources and thus influence …
Article scientifique
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
Abstract Collagen lysyl hydroxylases (LH1-3) are Fe2+- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause …
Article scientifique
Differentiated surface fungal communities at point of harvest on apple fruits from rural and peri-urban orchards
The diverse fungal communities that colonize fruit surfaces are closely associated with fruit development, preservation and quality control. However, the …
Article scientifique
Development of genome engineering technologies in cattle: from random to specific
The production of transgenic farm animals (e.g., cattle) via genome engineering for the gain or loss of gene functions is …
Article scientifique
RETRACTED ARTICLE: Occurrence and antimicrobial susceptibility profile of Escherichia coli O157:H7 from food of animal origin in Bishoftu town, Central Ethiopia
Abstract Background Escherichia coli O157:H7 ( E. coli O157:H7) have frequently been associated with food borne illness and are considered …
Article scientifique
Genome-wide association study in Asia-adapted tropical maize reveals novel and explored genomic regions for sorghum downy mildew resistance
Globally, downy mildews are among the important foliar diseases of maize that cause significant yield losses. We conducted a genome-wide …
Article scientifique
Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin
BACKGROUND: TGF-β signaling pathways regulate several crucial processes in female reproduction. AKT is a non-SMAD signaling pathway regulated by TGF-β …
Article scientifique
MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance
High rates of lethal outcome in tumour metastasis are associated with the acquisition of invasiveness and chemoresistance. Several clinical studies …
Article scientifique
In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3′,4′,7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria
BACKGROUND: Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but …
Article scientifique
Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
Abstract Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due …
Article scientifique
Antibacterial activity of antipsychotic agents, their association with lipid nanocapsules and its impact on the properties of the nanocarriers and on antibacterial activity
Bacterial antibiotic resistance is an emerging public health problem worldwide; therefore, new therapeutic strategies are needed. Many studies have described …