114 publication(s) trouvée(s)
Article scientifique
Efficacy of umbilical cord cleansing with a single application of 4% chlorhexidine for the prevention of newborn infections in Uganda: study protocol for a randomized controlled trial
BACKGROUND: Yearly, nearly all the estimated worldwide 2.7 million neonatal deaths occur in low- and middle-income countries. Infections, including those …
Article scientifique
Investigating interventions to increase uptake of HIV testing and linkage into care or prevention for male partners of pregnant women in antenatal clinics in Blantyre, Malawi: study protocol for a cluster randomised trial
BACKGROUND: Despite large-scale efforts to diagnose people living with HIV, 54% remain undiagnosed in sub-Saharan Africa. The gap in knowledge …
Article scientifique
Ciprofloxacin for contacts of cases of meningococcal meningitis as an epidemic response: study protocol for a cluster-randomized trial
BACKGROUND: Epidemics of meningococcal meningitis are common in the "African meningitis belt." Current response strategies include reactive vaccination campaigns, which …
Article scientifique
Simulating therapeutic drug monitoring results for dose individualisation to maintain investigator blinding in a randomised controlled trial
BACKGROUND: Therapeutic drug monitoring (TDM) is essential practice when dosing drugs with a narrow therapeutic index in order to achieve …
Article scientifique
Avoidable waste related to inadequate methods and incomplete reporting of interventions: a systematic review of randomized trials performed in Sub-Saharan Africa
BACKGROUND: Randomized controlled trials (RCTs) are needed to improve health care in Sub-Saharan Africa (SSA). However, inadequate methods and incomplete …
Article scientifique
Improving child nutrition and development through community-based childcare centres in Malawi – The NEEP-IE study: study protocol for a randomised controlled trial
BACKGROUND: The Nutrition Embedded Evaluation Programme Impact Evaluation (NEEP-IE) study is a cluster randomised controlled trial designed to evaluate the …
Article scientifique
Does the use of the Informed Healthcare Choices (IHC) primary school resources improve the ability of grade-5 children in Uganda to assess the trustworthiness of claims about the effects of treatments: protocol for a cluster-randomised trial
BACKGROUND: The ability to appraise claims about the benefits and harms of treatments is crucial for informed health care decision-making. …
Article scientifique
The effect of a clinical decision-making mHealth support system on maternal and neonatal mortality and morbidity in Ghana: study protocol for a cluster randomized controlled trial
BACKGROUND: Mobile health (mHealth) presents one of the potential solutions to maximize health worker impact and efficiency in an effort …
Article scientifique
Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial
BACKGROUND: Bacillus Calmette-Guérin (BCG) vaccination may have nonspecific effects, i.e., effects on childhood morbidity and mortality that go beyond its …
Article scientifique
The Benefits of Early Book Sharing (BEBS) for child cognitive and socio-emotional development in South Africa: study protocol for a randomised controlled trial
BACKGROUND: Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. …
Article scientifique
Challenges to complete and useful data sharing
Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise …
Article scientifique
Efficacy of vitamin D3 supplementation in reducing incidence of pulmonary tuberculosis and mortality among HIV-infected Tanzanian adults initiating antiretroviral therapy: study protocol for a randomized controlled trial
HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the …
Article scientifique
Can an educational podcast improve the ability of parents of primary school children to assess the reliability of claims made about the benefits and harms of treatments: study protocol for a randomised controlled trial
BACKGROUND: Claims made about the effects of treatments are very common in the media and in the population more generally. …
Article scientifique
The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials
BACKGROUND: -agonist (SABA) reliever medication and under-treatment of the underlying inflammation, with poor control of asthma symptoms and increased risk …
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