24 publication(s) trouvée(s)
Article scientifique
The alternative cap-binding complex is required for antiviral defense in vivo
Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression …
Article scientifique
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
Prion or PrPSc is the proteinaceous infectious agent causing prion diseases in various mammalian species. Despite decades of research, the …
Article scientifique
Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have …
Article scientifique
IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody
Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with …
Article scientifique
Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage
Previously we have described the V2-directed CAP256-VRC26 lineage that includes broadly neutralizing antibodies (bNAbs) that neutralize globally diverse strains of …
Article scientifique
Emergomyces: The global rise of new dimorphic fungal pathogens
Unknown until recently, the genus Emergomyces is composed of dimorphic fungi with human pathogenic potential.Five described species have been implicated …
Article scientifique
Roles, function and relevance of LAG3 in HIV infection
HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV.Immune exhaustion describes …
Article scientifique
Pneumocystis and interactions with host immune receptors
Article scientifique
Habits of a highly successful cereal killer, Striga
Article scientifique
Consequences of insecticide resistance on malaria transmission
Malaria burden and controlHuman malaria is caused by protozoan parasites of the genus Plasmodium (Plasmodium falciparum, P. vivax, P. malariae, …
Article scientifique
Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection
[This corrects the article DOI: 10.1371/journal.ppat.1006389.].
Article scientifique
Rapid identification of genes controlling virulence and immunity in malaria parasites
Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions …
Article scientifique
Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity
Prions, characterized by self-propagating protease-resistant prion protein (PrP) conformations, are agents causing prion disease. Recent studies generated several such self-propagating …
Article scientifique
Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection
In order to inform the rational design of HIV-1 preventive and cure interventions it is critical to understand the events …
Article scientifique
Signaling C-type lectin receptors in antimycobacterial immunity
Introduction \nThe mammalian innate immune system is composed of phagocytes such as macrophages and dendritic cells that serve as the …
Article scientifique
Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis
T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7) availability and receptivity. Regulation of IL-7 …
Article scientifique
Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection
Signals modulating the production of Mycobacterium tuberculosis (Mtb) virulence factors essential for establishing long-term persistent infection are unknown. The WhiB3 …
Article scientifique
Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue
Dengue is the most prevalent human arbovirus disease worldwide. Dengue virus (DENV) infection causes syndromes varying from self-limiting febrile illness …
Article scientifique
Immune correlates of HIV-associated cryptococcal meningitis
The International Society for Burns Injuries (ISBI) has published guidelines for the management of multiple or mass burns casualties, and …
Article scientifique
Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance
The dynamics of the memory CD8 T cell receptor (TCR) repertoire upon virus re-exposure and factors governing the selection of …
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