7 publication(s) trouvée(s)
Article scientifique
Distinct domains of Escherichia coli IgaA connect envelope stress sensing and down-regulation of the Rcs phosphorelay across subcellular compartments
In enterobacteria, the Rcs system (Regulator of capsule synthesis) monitors envelope integrity and induces a stress response when damages occur …
Article scientifique
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania
Significant selection pressure has been exerted on the genomes of human populations exposed to Plasmodium falciparum infection, resulting in the …
Article scientifique
A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa
One in three people has been infected with Mycobacterium tuberculosis (MTB), and the risk for MTB infection in HIV-infected individuals …
Article scientifique
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations
Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden …
Article scientifique
Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies
Schinzel-Giedion syndrome (SGS) is a rare developmental disorder characterized by multiple malformations, severe neurological alterations and increased risk of malignancy. …
Article scientifique
Genomic Footprints of Selective Sweeps from Metabolic Resistance to Pyrethroids in African Malaria Vectors Are Driven by Scale up of Insecticide-Based Vector Control
Insecticide resistance in mosquito populations threatens recent successes in malaria prevention. Elucidating patterns of genetic structure in malaria vectors to …
Article scientifique
Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data
The rate of germline mutation varies widely between species but little is known about the extent of variation in the …