1170 publication(s) trouvée(s)
Article scientifique
Prevalence of Plasmodium falciparum and non-P. falciparum infections in a highland district in Ghana, and the influence of HIV and sickle cell disease
BACKGROUND: In the past two decades, there has been a reported decline in malaria in Ghana and the rest of …
Article scientifique
The end of a dogma: the safety of doxycycline use in young children for malaria treatment
Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance …
Article scientifique
Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity
BACKGROUND: In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The …
Article scientifique
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria …
Article scientifique
Caregivers’ perception of malaria and treatment-seeking behaviour for under five children in Mandura District, West Ethiopia: a cross-sectional study
BACKGROUND: Early diagnosis and prompt malaria treatment is essential to reduce progression of the illness to severe disease and, therefore, …
Article scientifique
Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and …
Article scientifique
Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda
BACKGROUND: Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children …
Article scientifique
Assessment of the utility of a symptom-based algorithm for identifying febrile patients for malaria diagnostic testing in Senegal
BACKGROUND: Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The …
Article scientifique
Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015
BACKGROUND: In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for …
Article scientifique
Selections, frameshift mutations, and copy number variation detected on the surf 4.1 gene in the western Kenyan Plasmodium falciparum population
Plasmodium falciparum SURFIN4.1 is a putative ligand expressed on the merozoite and likely on the infected red blood cell, whose …
Article scientifique
Predictors of the use of interventions to prevent malaria in pregnancy in Cameroon
BACKGROUND: Malaria in pregnancy is common in sub-Saharan Africa where it contributes to perinatal morbidity and mortality. Use of insecticide-treated …
Article scientifique
Preliminary survey on Anopheles species distribution in Botswana shows the presence of Anopheles gambiae and Anopheles funestus complexes
BACKGROUND: Botswana is one of the four front line malaria elimination countries in Southern Africa, with malaria control activities that …
Article scientifique
In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products
BACKGROUND: Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), …
Article scientifique
Burden of malaria in mobile populations in the Greater Accra region, Ghana: a cross- sectional study
BACKGROUND: The burden of malaria in mobile populations remains poorly documented in sub-Saharan Africa. This study determined the prevalence of …
Article scientifique
Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda
BACKGROUND: Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns …
Article scientifique
Assessing the impact of differences in malaria transmission intensity on clinical and haematological indices in children with malaria
BACKGROUND: Malaria control interventions have led to a decline in transmission intensity in many endemic areas, and resulted in elimination …
Article scientifique
Reemergence of chloroquine-sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon
BACKGROUND: Chloroquine had been used extensively during the last five decades in Cameroon. Its decreasing clinical effectiveness, supported by high …
Article scientifique
The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia
The widespread presence of low-density asymptomatic infections with concurrent gametocytes may be a stumbling block for malaria elimination. This study …
Article scientifique
A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria
BACKGROUND: Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside …
Article scientifique
Analytical sensitivity of current best-in-class malaria rapid diagnostic tests
BACKGROUND: Rapid diagnostic tests (RDTs) are today the most widely used method for malaria diagnosis and are recommended, alongside microscopy, …