1077 publication(s) trouvée(s)
Article scientifique
When it just won’t go away: oral artemisinin monotherapy in Nigeria, threatening lives, threatening progress
Oral artemisinin monotherapy (AMT), an important contributor to multi-drug resistant malaria, has been banned in Nigeria. While oral AMT has …
Article scientifique
In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine
Discovery of novel gametocytocidal molecules is a major pharmacological strategy in the elimination and eradication of malaria. The high patronage …
Article scientifique
Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children
BACKGROUND: Young children are at greatest risk for malaria-associated morbidity and mortality. The immune response of young children differs in …
Article scientifique
Why some sites are responding better to anti-malarial interventions? A case study from western Kenya
BACKGROUND: In sub-Saharan Africa, malaria interventions over the last decades have been successful in reducing both mortality and morbidity. In …
Article scientifique
The malaria testing and treatment landscape in Kenya: results from a nationally representative survey among the public and private sector in 2016
BACKGROUND: Since 2004, Kenya's national malaria treatment guidelines have stipulated artemisinin-based combination therapy (ACT) as first-line treatment for uncomplicated malaria, …
Article scientifique
Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections
BACKGROUND: During intra-erythrocytic replication Plasmodium falciparum escapes the human host immune system by switching expression of variant surface antigens (VSA). …
Article scientifique
Temporal variation in confirmed diagnosis of fever-related malarial cases among children under-5 years by community health workers and in health facilities between years 2013 and 2015 in Siaya County, Kenya
BACKGROUND: Malaria case management continues to experience dynamic changes. Building community capacity is instrumental in both prevention and treatment of …
Article scientifique
Age-specific Plasmodium parasite profile in pre and post ITN intervention period at a highland site in western Kenya
BACKGROUND: Monitoring and evaluation of entomological, parasitological and clinical data is an important component of malaria control as it is …
Article scientifique
Variation in the immune responses against Plasmodium falciparum merozoite surface protein-1 and apical membrane antigen-1 in children residing in the different epidemiological strata of malaria in Cameroon
Studies to assess the immune responses against malaria in Cameroonian children are limited. The purpose of this study was to …
Article scientifique
Shifting the burden or expanding access to care? Assessing malaria trends following scale-up of community health worker malaria case management and reactive case detection
BACKGROUND: Malaria is a significant burden to health systems and is responsible for a large proportion of outpatient cases at …
Article scientifique
Malaria prevalence metrics in low- and middle-income countries: an assessment of precision in nationally-representative surveys
BACKGROUND: One pillar to monitoring progress towards the Sustainable Development Goals is the investment in high quality data to strengthen …
Article scientifique
Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda
BACKGROUND: Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective …
Article scientifique
Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study
BACKGROUND: Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of …
Article scientifique
Determination of the residual efficacy of carbamate and organophosphate insecticides used for indoor residual spraying for malaria control in Ethiopia
Indoor residual spraying is one of the key vector control interventions for malaria control in Ethiopia. As malaria transmission is …
Article scientifique
Malaria early warning tool: linking inter-annual climate and malaria variability in northern Guadalcanal, Solomon Islands
BACKGROUND: Malaria control remains a significant challenge in the Solomon Islands. Despite progress made by local malaria control agencies over …
Article scientifique
Quantifying seasonal and diel variation in Anopheline and Culex human biting rates in Southern Ecuador
BACKGROUND: Quantifying mosquito biting rates for specific locations enables estimation of mosquito-borne disease risk, and can inform intervention efforts. Measuring …
Article scientifique
Micro-spatial distribution of malaria cases and control strategies at ward level in Gwanda district, Matabeleland South, Zimbabwe
BACKGROUND: Although there has been a decline in the number of malaria cases in Zimbabwe since 2010, the disease remains …
Article scientifique
A village level cluster-randomized entomological evaluation of combination long-lasting insecticidal nets containing pyrethroid plus PBO synergist in Southern Mali
BACKGROUND: There is growing concern that malaria vector resistance to pyrethroid insecticides may reduce the effectiveness of long-lasting insecticidal nets …
Article scientifique
Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays
BACKGROUND: The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection …
Article scientifique
Receptivity to malaria in the China–Myanmar border in Yingjiang County, Yunnan Province, China
BACKGROUND: The re-establishment of malaria has become an important public health issue in and out of China, and receptivity to …