19 publication(s) trouvée(s)
Article scientifique
Correction to: Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy
Following publication of the original article [1], the authors reported errors in Figures 2, 3 and Figure 3 'continued'.
Article scientifique
Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture?
BACKGROUND: Meningitis can be caused by several viruses and bacteria. Identifying the causative pathogen as quickly as possible is crucial …
Article scientifique
Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia
BACKGROUND: Triple negative breast cancer (TNBC) has been classified as a disease subgroup defined by the lack of expression of …
Article scientifique
Identification of potential miRNA–mRNA regulatory network contributing to pathogenesis of HBV-related HCC
BACKGROUND: Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that …
Article scientifique
Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition
BACKGROUND: Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs) …
Article scientifique
The immune response to sub-clinical mastitis is impaired in HIV-infected women
BACKGROUND: Subclinical mastitis (SCM) is relatively common in lactating women and may be associated with HIV shedding in breast milk. …
Article scientifique
Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway
BACKGROUND: The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility …
Article scientifique
Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly attributing to its high tendency to metastasis. Vascular …
Article scientifique
A prospective study on the changes and clinical significance of pre-operative and post-operative circulating tumor cells in resectable gastric cancer
BACKGROUND: Circulating tumor cells (CTCs) have been suggested as potential prognostic indicators for multiple tumors, including gastric cancer; however, pre- …
Article scientifique
Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases
BACKGROUND: A family history of breast cancer has long been thought to indicate the presence of inherited genetic events that …
Article scientifique
Effects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models: a systematic review and meta-analysis
It has been reported mesenchymal stem cells (MSCs) are recruited to and become integral parts of the tumor microenvironment. MSCs …
Article scientifique
Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case–control study
BACKGROUND: This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced …
Article scientifique
Improving cancer detection through combinations of cancer and immune biomarkers: a modelling approach
BACKGROUND: Early cancer diagnosis is one of the most important challenges of cancer research, since in many cancers it can …
Article scientifique
Establishment and genomic characterizations of patient-derived esophageal squamous cell carcinoma xenograft models using biopsies for treatment optimization
BACKGROUND: Squamous cell carcinoma is the dominant type of esophageal cancer in China with many patients initially diagnosed at advanced …
Article scientifique
Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways
BACKGROUND: We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan and irinotecan in gastric cancer …
Article scientifique
CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest
BACKGROUND: Cell cycle dysregulation is common in human malignancies, and CDK4/6 inhibitors targeting cell cycle have potential antitumor activity. SHR6390 …
Article scientifique
Anti-inflammatory effects of H2S during acute bacterial infection: a review
Hydrogen sulfide (H 2 S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important …
Article scientifique
The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological …
Article scientifique
Cystic fibrosis: current therapeutic targets and future approaches
OBJECTIVES: Study of currently approved drugs and exploration of future clinical development pipeline therapeutics for cystic fibrosis, and possible limitations …