115 publication(s) trouvée(s)
Article scientifique
Caveolin-1 Controls Vesicular TLR2 Expression, p38 Signaling and T Cell Suppression in BCG Infected Murine Monocytic Myeloid-Derived Suppressor Cells
Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs) have been found to be massively induced in TB patients as …
Article scientifique
Capacity to Elicit Cytotoxic CD8 T Cell Activity Against Mycobacterium avium subsp. paratuberculosis Is Retained in a Vaccine Candidate 35 kDa Peptide Modified for Expression in Mammalian Cells
Studies focused on development of an attenuated vaccine against Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of paratuberculosis (Ptb) …
Article scientifique
Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon
Background: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 …
Article scientifique
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as …
Article scientifique
Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway
Both neutralization and antibody-dependent cellular cytotoxicity (ADCC) may be required for effective protection against HIV-1 infection. While there is extensive …
Article scientifique
FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response
Alveolar Macrophages play a key role in the development of a robust adaptive immune response against the agent of Tuberculosis …
Article scientifique
PI3-Kinase δγ Catalytic Isoforms Regulate the Th-17 Response in Tuberculosis
IL-17A plays a protective role at the mucosal surface, however when IL-17A signalling becomes dysregulated, a pathological immune response is …
Article scientifique
Chronic Intestinal Pseudo-Obstruction and Lymphoproliferative Syndrome as a Novel Phenotype Associated With Tetratricopeptide Repeat Domain 7A Deficiency
Mutations in the tetratricopeptide repeat domain 7A (TTC7A) gene cause very early onset inflammatory bowel diseases (VOIBD) or multiple intestinal …
Article scientifique
The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils
Production of superoxide anion and other reactive oxygen species (ROS) by neutrophils has a vital role in host defense against …
Article scientifique
Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages
In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of …
Article scientifique
Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells
The secondary analyses for correlates of risk of infection in the RV144 HIV-1 vaccine trial implicated vaccine-induced antibody-dependent cellular cytotoxicity …
Article scientifique
Dendritic Cells Generated From Mops condylurus, a Likely Filovirus Reservoir Host, Are Susceptible to and Activated by Zaire Ebolavirus Infection
Ebola virus infection of human dendritic cells (DCs) induces atypical adaptive immune responses and thereby exacerbates Ebola virus disease (EVD). …
Article scientifique
Exploring Plasmodium falciparum Var Gene Expression to Assess Host Selection Pressure on Parasites During Infancy
In sub-Saharan Africa, children below five years bear the greatest burden of severe malaria because they lack naturally acquired immunity …
Article scientifique
Understanding P. falciparum Asymptomatic Infections: A Proposition for a Transcriptomic Approach
Malaria is still a significant public health burden in the tropics. Infection with malaria causing parasites results in a wide …
Article scientifique
Disruption of the preB Cell Receptor Complex Leads to Decreased Bone Mass
In the bone marrow, preB cells are found adjacent to the bone endosteum where bone synthesizing osteoblast and bone resorbing …
Article scientifique
Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury
Proteinuria is an adverse prognostic feature in renal diseases. In proteinuric nephropathies, filtered proteins exert an injurious effect on the …
Article scientifique
Short-Lived Immunity After 17DD Yellow Fever Single Dose Indicates That Booster Vaccination May Be Required to Guarantee Protective Immunity in Children
The Yellow Fever (YF) vaccination is recommended for people living in endemic areas and represents the most effective strategy to …
Article scientifique
Airway CD8+CD161++TCRvα7.2+ T Cell Depletion During Untreated HIV Infection Targets CD103 Expressing Cells
HIV-infected adults are at an increased risk to lower respiratory tract infections. CD8+CD161++TCRvalpha7.2+ T cells are an innate-like T cell …
Article scientifique
Immunology Education Without Borders
One of the mandates of the International Union of Immunological Societies (IUIS) is to promote immunological education to young scientists …
Article scientifique
TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling
Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) knockout (KO) cells were generated to investigate the role of TRAF2 in …
1 / 6
Suivant →