46 publication(s) trouvée(s)
Article scientifique
The African Genomic Medicine Training Initiative (AGMT): Showcasing a Community and Framework Driven Genomic Medicine Training for Nurses in Africa
The potential of genomic medicine in improving the quality of healthcare both at population and individual-level is well-recognized globally. However, …
Article scientifique
Population Structure and Genetic Diversity of Nile Tilapia (Oreochromis niloticus) Strains Cultured in Tanzania
Understanding population structure and genetic diversity within and between local Nile tilapia lines cultured in Tanzania is important for sustainable …
Article scientifique
Whole Genome Resequencing Reveals Selection Signatures Associated With Important Traits in Ethiopian Indigenous Goat Populations
Ethiopia is considered as the main gateway for the introduction of livestock species including goat to the African continent. Ethiopian …
Article scientifique
DNA Data Marketplace: An Analysis of the Ethical Concerns Regarding the Participation of the Individuals
Personal genomic data and the related health data are valuable resources for both public-funded research, and for-profit entities in development …
Article scientifique
Genetic Connectivity of the Sky Emperor, Lethrinus mahsena Populations Across a Gradient of Exploitation Rates in Coastal Kenya
Marine Protected Areas (MPAs) have the potential to enhance fisheries through transport of larvae or by a net emigration of …
Article scientifique
Establishing a Multi-Country Sickle Cell Disease Registry in Africa: Ethical Considerations
Sickle cell disease (SCD) is one of the most prevalent genetic conditions in sub-Saharan Africa. It is a chronic, lifelong …
Article scientifique
GTn Repeat Microsatellite Instability in Uterine Fibroids
Background: Type I collagen is a triple helix structure with two α1 and one α2 chains. Coordinated biosynthesis of α1 …
Article scientifique
Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets
Lennert lymphoma (LL) is a lymphoepithelioid morphological variant of peripheral T-cell lymphoma-not otherwise specified (PTCL/NOS), clinically characterized by better prognosis …
Article scientifique
The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center
Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond …
Article scientifique
GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana
Our study aimed to investigate GJB2 (connexin 26) and GJB6 (connexin 30) mutations associated with non-syndromic childhood hearing impairment (HI) …
Article scientifique
Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing
Whole genome sequencing is being rapidly applied to the study of helminth genomes, including de novo genome assembly, population genetics, …
Article scientifique
Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus
The etiology of dental anomalies is multifactorial; and genetic and environmental factors that affect the dental lamina have been implicated. …
Article scientifique
Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data
Background: Tuberculosis disease, caused by Mycobacterium tuberculosis, is a major public health problem. The emergence of M. tuberculosis strains resistant …
Article scientifique
The Potential Role of Regulatory Genes (DNMT3A, HDAC5, and HDAC9) in Antipsychotic Treatment Response in South African Schizophrenia Patients
Despite advances in pharmacogenetics the majority of heritability for treatment response cannot be explained by common variation, suggesting that factors …
Article scientifique
Timing and Extent of Inbreeding in African Goats
Genetic characterization of African goats is one of the current priorities in the improvement of goats in the continent. This …
Article scientifique
Dissecting in silico Mutation Prediction of Variants in African Genomes: Challenges and Perspectives
Genomic medicine is set to drastically improve clinical care, globally, due to high throughput technologies, which enable speedy in silico …
Article scientifique
Cellular and Molecular Adaptation of Arabian Camel to Heat Stress
) has developed exceptional physiological and biochemical particularities. Previous reports focused mainly on the physiological features of Arabian camel and …
Article scientifique
Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa
Hydroxyurea (HU) is clinically beneficial in Sickle Cell Disease (SCD) through foetal haemoglobin (HbF) induction; however, the mechanism of HU …
Article scientifique
The Relationship Between Environmental Exposure and Genetic Architecture of the 2q33 Locus With Esophageal Cancer in South Africa
Oesophageal squamous cell carcinoma (OSCC) has a high prevalence in several countries in Africa and Asia. Previous genome-wide association studies …
Article scientifique
Performance Evaluation of Highly Admixed Tanzanian Smallholder Dairy Cattle Using SNP Derived Kinship Matrix
The main purpose of this study was to understand the type of dairy cattle that can be optimally used by …
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