6 publication(s) trouvée(s)
Article scientifique
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation …
Article scientifique
Assessment of new HDAC inhibitors for immunotherapy of malignant pleural mesothelioma
Background: Malignant pleural mesothelioma (MPM) is a very rare and highly aggressive cancer of the pleura associated in most cases …
Article scientifique
Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma
BACKGROUND: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that …
Article scientifique
Transcriptomics and methylomics in chronic periodontitis with tobacco use: a pilot study
BACKGROUND: Accumulating evidence suggests that tobacco smoking affects the susceptibility to and severity of chronic periodontitis. Epigenetics may explain the …
Article scientifique
Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs
BACKGROUND: Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability …
Article scientifique
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
The CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment …