7 publication(s) trouvée(s)
Article scientifique
CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis
A unique feature of CD40 among the TNF receptor (TNFR) superfamily is its exquisitely contextual effects, as originally demonstrated in …
Article scientifique
Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) shows a high level of basal autophagy. Here we investigated the role of optineurin (OPTN) in …
Article scientifique
The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells
Abstract Rhabdomyosarcoma (RMS) forms in skeletal muscle and is the most common soft tissue sarcoma in children and adolescents. Current …
Article scientifique
Tumor treating fields increases membrane permeability in glioblastoma cells
Glioblastoma is the most common yet most lethal of primary brain cancers with a one-year post-diagnosis survival rate of 65% …
Article scientifique
DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile
Docosahexaenoic acid (DHA) and their CYP-derived metabolites, epoxydocosapentaenoic acids (EDPs), are important fatty acids obtained from dietary sources. While it …
Article scientifique
Fountain of youth of pancreatic cancer cells: the extracellular matrix
The microenvironment of tumors varies between cancer types, and its complex role in tumor propagation contributes to its importance in …
Article scientifique
Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array
Abstract The balance between acetylation and deacetylation of histone proteins plays a critical role in the regulation of genomic functions. …