26 publication(s) trouvée(s)
Article scientifique
Magnitude and causes of first-line antiretroviral therapy regimen changes among HIV patients in Ethiopia: a systematic review and meta-analysis
Abstract Background Antiretroviral therapy (ART) has markedly decreased the morbidity and mortality due to HIV/AIDS. ART regimen change is a …
Article scientifique
RETRACTED ARTICLE: Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice
BACKGROUND: Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-colitic. …
Article scientifique
Analysis of severe adverse effects following community-based ivermectin treatment in the Democratic Republic of Congo
BACKGROUND: The progress of mass, community-directed, treatment with ivermectin (CDTI) for onchocerciasis control was disrupted by severe adverse effects (SAE) …
Article scientifique
Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis
Experimental pharmacology deals with effects of various test substances studied on different animal species which is aimed at finding out …
Article scientifique
Nature and prevalence of adverse drug reaction of antiretroviral medications in Halibet National Referral Hospital: a retrospective study
BACKGROUND: Monitoring the safety of antiretroviral therapy (ART) remains a challenge in resource-constrained countries such as Eritrea due to their …
Article scientifique
Microbial epidemiology and antimicrobial resistance patterns of wound infection in Ethiopia: a meta-analysis of laboratory-based cross-sectional studies
BACKGROUND: Wound infections are responsible for significant human morbidity and mortality worldwide. Specifically, surgical site infections are the third most …
Article scientifique
Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study
BACKGROUND: Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used …
Article scientifique
Quality of albendazole tablets legally circulating in the pharmaceutical market of Addis Ababa, Ethiopia: physicochemical evaluation
BACKGROUND: Parasitic diseases are the main challenge of livestock production in the world. They are mainly controlled by the use …
Article scientifique
Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles
BACKGROUND: Nanotechnology is now considered a promising drug delivery method for orally administered hydrophobic drugs to their sites of action. …
Article scientifique
Evaluation of free radical scavenging capacity of methoxy containing-hybrids of thiosemicarbazone-triazole and their influence on glucose transport
BACKGROUND: Diabetes mellitus is a metabolic disease in which the body is unable to produce insulin or respond to insulin …
Article scientifique
Resistance profile of clinically relevant bacterial isolates against fluoroquinolone in Ethiopia: a systematic review and meta-analysis
Fluoroquinolones are among the most frequently utilized antibacterial agents in developing countries like Ethiopia. Ciprofloxacin has become the most prescribed …
Article scientifique
Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania
BACKGROUND: Children are subject to varying drug pharmacokinetics which influence plasma drug levels, and hence treatment outcomes especially for drugs …
Article scientifique
Toxicological evaluation of therapeutic and supra-therapeutic doses of Cellgevity® on reproductive function and biochemical indices in Wistar rats
BACKGROUND: The misconception about dietary supplements being safe has led many into the in-patient wards. Cellgevity® (CGV) is a Max …
Article scientifique
Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress
BACKGROUND: Nanoparticles are widely utilized in many products such as cosmetics and sunscreens. The present study was undertaken to evaluate …
Article scientifique
Epidemiology of self-medication in Ethiopia: a systematic review and meta-analysis of observational studies
Self-medication is the use of drugs to treat self-diagnosed disorders and/or symptoms, or the intermittent or continued use of a …
Article scientifique
Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115
L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic …
Article scientifique
Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum
Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for …
Article scientifique
Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators
BACKGROUND: WHO pharmacovigilance indicators have been recommended as a useful tool towards improving pharmacovigilance activities. Nigeria with a myriad of …
Article scientifique
Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with infection at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
BACKGROUND: Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development …
Article scientifique
Prevalence of borrowing and sharing prescription medicines and associated socio-demographic factors: findings from COBERS health centres in northern Uganda
BACKGROUND: The use of prescription medications without the involvement of medical professionals is a growing public health concern. Therefore this …
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