558 publication(s) trouvée(s)
Article scientifique
A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice
Abstract Background Although DAAs hold promise to significantly reduce rates of chronic HCV infections, its eradication still requires development of …
Article scientifique
Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs
BACKGROUND: Fluoroquinolones are commonly recommended as treatment for urinary tract infections (UTIs). The development of resistance to these agents, particularly …
Article scientifique
Bacteriological profile, risk factors and antimicrobial susceptibility patterns of symptomatic urinary tract infection among students of Mekelle University, northern Ethiopia
BACKGROUND: Bacterial infection of the urinary tract is among the common reasons for seeking medical attention in the community. Rapidly …
Article scientifique
A prevalence survey of enteral parasites in preschool children in the Mangochi District of Malawi
BACKGROUND: Helminthic and protozoan infections are common, particularly in low- or middle-income countries. Although an association between parasite carriage and …
Article scientifique
Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study
BACKGROUND: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease globally. Direct acting antivirals (DAAs) have …
Article scientifique
Intensified household contact tracing, prevention and treatment support versus enhanced standard of care for contacts of tuberculosis cases in South Africa: study protocol for a household cluster-randomised trial
BACKGROUND: Household contact tracing of index TB cases has been advocated as a key part of TB control for many …
Article scientifique
Prevalence of active trachoma and associated factors among children aged 1 to 9 years in rural communities of Lemo district, southern Ethiopia: community based cross sectional study
BACKGROUND: Trachoma, caused by Chlamydia trachomatis is the leading infectious cause of blindness. It is transmitted via personal contact with …
Article scientifique
Bayesian modeling of spatiotemporal patterns of TB-HIV co-infection risk in Kenya
Abstract Background Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) diseases are globally acknowledged as a public health challenge that exhibits …
Article scientifique
Multiple sequence types responsible for healthcare-associated Acinetobacter baumannii dissemination in a single centre in Egypt
Abstract Background Acinetobacter baumannii is an increasingly worrying organism in the healthcare setting, due to its multidrug resistance and persistence. …
Article scientifique
Interpreting HIV diagnostic histories into infection time estimates: analytical framework and online tool
BACKGROUND: It is frequently of epidemiological and/or clinical interest to estimate the date of HIV infection or time-since-infection of individuals. …
Article scientifique
Diabetes mellitus among patients attending TB clinics in Dar es Salaam: a descriptive cross-sectional study
BACKGROUND: A bi-directional interaction between diabetes mellitus and tuberculosis is well established and has been likened to that between HIV …
Article scientifique
Intestinal schistosomiasis of Ijinga Island, north-western Tanzania: prevalence, intensity of infection, hepatosplenic morbidities and their associated factors
BACKGROUND: Intestinal schistosomiasis is highly endemic in Tanzania and mass drug administration (MDA) using praziquantel is the mainstay of the …
Article scientifique
Comparison of GeneXpert and line probe assay for detection of Mycobacterium tuberculosis and rifampicin-mono resistance at the National Tuberculosis Reference Laboratory, Kenya
BACKGROUND: The dual challenge of low diagnostic sensitivity of microscopy test and technical challenge of performing a TB culture test …
Article scientifique
The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo
BACKGROUND: Drug resistant malaria is a growing concern in the Democratic Republic of the Congo (DRC), where previous studies indicate …
Article scientifique
Chromosomal and plasmid-mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana
BACKGROUND: Salmonella infection poses significant public health threat globally, especially in resource-limited countries. Emergence and spread of antibiotic resistant strains …
Article scientifique
blaVIM- and blaOXA-mediated carbapenem resistance among Acinetobacter baumannii and Pseudomonas aeruginosa isolates from the Mulago hospital intensive care unit in Kampala, Uganda
Abstract Background Between January 2015 and July 2017, we investigated the frequency of carbapenem resistant Acinetobacter baumannii (CRAB) and carbapenem …
Article scientifique
Broad spectrum resistance in Helicobacter pylori isolated from gastric biopsies of patients with dyspepsia in Cameroon and efflux-mediated multiresistance detection in MDR isolates
BACKGROUND: Antibiotic resistance is a leading cause of treatment failure in Helicobacter pylori infection. In Africa, there are very little …
Article scientifique
Cutaneous leishmaniasis a neglected tropical disease: community knowledge, attitude and practices in an endemic area, Northwest Ethiopia
BACKGROUND: Cutaneous leishmaniasis is one of the neglected tropical diseases in the Ethiopian highlands and studies on assessment of knowledge, …
Article scientifique
An approach for evaluating early and long term mother-to-child transmission of HIV (MTCT) in low and middle income countries: a South African experience
BACKGROUND: Eliminating mother-to-child transmission of HIV is a global public health target. Robust, feasible methodologies to measure population level impact …
Article scientifique
Infrastructural and human-resource factors associated with return of infant HIV test results to caregivers: secondary analysis of a nationally representative situational assessment, South Africa, 2010
BACKGROUND: In June 2015, South Africa introduced early infant HIV diagnosis (EID) at birth and ten weeks postpartum. Guidelines recommended …