57 publication(s) trouvée(s)
Article scientifique
Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data
BACKGROUND: Mixed, polyclonal Mycobacterium tuberculosis infection occurs in natural populations. Developing an effective method for detecting such cases is important …
Article scientifique
Full-length transcriptome sequences and the identification of putative genes for flavonoid biosynthesis in safflower
BACKGROUND: The flower of the safflower (Carthamus tinctorius L.) has been widely used in traditional Chinese medicine for the ability …
Article scientifique
Genome-wide DNA methylation patterns of bovine blastocysts derived from in vivo embryos subjected to in vitro culture before, during or after embryonic genome activation
BACKGROUND: Aberrant DNA methylation patterns of genes required for development are common in in vitro produced embryos. In this regard, …
Article scientifique
EuGI: a novel resource for studying genomic islands to facilitate horizontal gene transfer detection in eukaryotes
BACKGROUND: Genomic islands (GIs) are inserts of foreign DNA that have potentially arisen through horizontal gene transfer (HGT). There are …
Article scientifique
Genome-wide transcriptional analyses in Anopheles mosquitoes reveal an unexpected association between salivary gland gene expression and insecticide resistance
BACKGROUND: To combat malaria transmission, the Ugandan government has embarked upon an ambitious programme of indoor residual spraying (IRS) with …
Article scientifique
Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data
BACKGROUND: The conventional variant calling of pathogenic alleles in exome and genome sequencing requires the presence of the non-pathogenic alleles …
Article scientifique
Dissection of the multigenic wheat stem rust resistance present in the Montenegrin spring wheat accession PI 362698
BACKGROUND: Research to identify and characterize stem rust resistance genes in common wheat, Triticum aestivum, has been stimulated by the …
Article scientifique
The genome of a prasinoviruses-related freshwater virus reveals unusual diversity of phycodnaviruses
BACKGROUND: Phycodnaviruses are widespread algae-infecting large dsDNA viruses and presently contain six genera: Chlorovirus, Prasinovirus, Prymnesiovirus, Phaeovirus, Coccolithovirus and Raphidovirus. …
Article scientifique
Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data
BACKGROUND: Runs of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection …
Article scientifique
Comparative analysis of avian poxvirus genomes, including a novel poxvirus from lesser flamingos (Phoenicopterus minor), highlights the lack of conservation of the central region
BACKGROUND: Avian poxviruses are important pathogens of both wild and domestic birds. To date, seven isolates from subclades A and …
Article scientifique
COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby
BACKGROUND: Two common single nucleotide polymorphisms within the COL5A1 gene (SNPs; rs12722 C/T and rs3196378 C/A) have previously been associated …
Article scientifique
Molecular basis of African yam domestication: analyses of selection point to root development, starch biosynthesis, and photosynthesis related genes
BACKGROUND: After cereals, root and tuber crops are the main source of starch in the human diet. Starch biosynthesis was …
Article scientifique
Genetic variation and population structure of maize inbred lines adapted to the mid-altitude sub-humid maize agro-ecology of Ethiopia using single nucleotide polymorphic (SNP) markers
BACKGROUND: Molecular characterization is important for efficient utilization of germplasm and development of improved varieties. In the present study, we …
Article scientifique
Mitochondrial genomes of African pangolins and insights into evolutionary patterns and phylogeny of the family Manidae
BACKGROUND: This study used next generation sequencing to generate the mitogenomes of four African pangolin species; Temminck's ground pangolin (Smutsia …
Article scientifique
Evolution and expression analysis reveal the potential role of the HD-Zip gene family in regulation of embryo abortion in grapes (Vitis vinifera L.)
BACKGROUND: The HD-Zip family has a diversity of functions during plant development. In this study, we identify 33 HD-Zip transcription …
Article scientifique
Screening of nucleotide variations in genomic sequences encoding charged protein regions in the human genome
BACKGROUND: Studying genetic variation distribution in proteins containing charged regions, called charge clusters (CCs), is of great interest to unravel …
Article scientifique
Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-arbovirus interference phenomenon
BACKGROUND: Aedes albopictus is a vector of arboviruses that cause severe diseases in humans such as Chikungunya, Dengue and Zika …
Article scientifique
Genomic, transcriptomic, and proteomic approaches towards understanding the molecular mechanisms of salt tolerance in Frankia strains isolated from Casuarina trees
BACKGROUND: Soil salinization is a worldwide problem that is intensifying because of the effects of climate change. An effective method …
Article scientifique
Transcriptional analysis of abdominal fat in chickens divergently selected on bodyweight at two ages reveals novel mechanisms controlling adiposity: validating visceral adipose tissue as a dynamic endocrine and metabolic organ
BACKGROUND: Decades of intensive genetic selection in the domestic chicken (Gallus gallus domesticus) have enabled the remarkable rapid growth of …
Article scientifique
Identification of long non-coding RNA in the horse transcriptome
BACKGROUND: Efforts to resolve the transcribed sequences in the equine genome have focused on protein-coding RNA. The transcription of the …