155 publication(s) trouvée(s)
Article scientifique
Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos
BACKGROUND: Influenza A virus (IAV) is still a major health threat. The clinical manifestations of this infection are related to …
Article scientifique
Ethno-pharmacological survey of herbal remedies used in the treatment of paediatric diseases in Buhunga parish, Rukungiri District, Uganda
BACKGROUND: Plants have been used as a primary source of medicine since ancient times and about 80% of the world's …
Article scientifique
Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats
Abstract Background Osteoarthritis (OA) is an age-related joint disease with characteristics that involve the progressive degradation of articular cartilage and …
Article scientifique
Antibacterial activities, proposed mode of action and cytotoxicity of leaf extracts from Triumfetta welwitschii against Pseudomonas aeruginosa
BACKGROUND: Pseudomonas aeruginosa has become a main cause of Gram-negative infection, particularly in patients with compromised immunity. High rates of …
Article scientifique
Cytotoxic activity of crude extracts from Datura stramonium’s fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling
BACKGROUND: Endophytic fungi are a proven source of bioactive secondary metabolites that may provide lead compounds for novel drug discovery. …
Article scientifique
Anti-inflammatory activities of astringent persimmons (Diospyros kaki Thunb.) stalks of various cultivar types based on the stages of maturity in the Gyeongnam province
BACKGROUND: Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. …
Article scientifique
Evaluation of antimicrobial activity of chondrillasterol isolated from Vernonia adoensis (Asteraceae)
BACKGROUND: Bacteria have developed resistance to most of the current antibiotics. There is evidence suggesting that plant-derived compounds have a …
Article scientifique
Evaluation of the in vitro effects of commercial herbal preparations significant in African traditional medicine on platelets
BACKGROUND: Commercial herbal medicines (CHMs) marketed as immune boosters are gaining wide popularity in South Africa, in the absence of …
Article scientifique
In vitro α-amylase inhibitory effect of TLC isolates of Aloe megalacantha baker and Aloe monticola Reynolds
About 425 million adults had diabetes mellitus globally in 2017. Type 2 diabetes accounts for the enormous majority of diabetes …
Article scientifique
Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice
BACKGROUND: Drug resistance poses a challenge to malaria control measures. This calls for discovery & development of new chemotherapeutic agents. …
Article scientifique
Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics
BACKGROUND: Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high …
Article scientifique
Inhibitory effects of Azadirachta indica secondary metabolites formulated cosmetics on some infectious pathogens and oxidative stress radicals
BACKGROUND: Infectious diseases, particularly those due to multi-drug resistant bacterial strains are almost impossible to cure globally. In this study …
Article scientifique
Cannabinoid-deficient Benin republic hemp (Cannabis sativa L.) improves semen parameters by reducing prolactin and enhancing anti-oxidant status
BACKGROUND: Nigerian Cannabis sativa (hemp) causes male gonadotoxicity by inducing hyperprolactinemia, down-regulation of hypothalamic-pituitary-testicular axis, and oxidative stress. Benin republic …
Article scientifique
Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria
BACKGROUND: Albizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the …
Article scientifique
Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas
There is increasing interest in the pharmaceutical and food industries to substitute synthetic chemicals with naturally occurring compounds possessing bioactive …
Article scientifique
Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity
BACKGROUND: Tuberculosis is a deadly disease caused by Mycobacterium species. The use of medicinal plants is an ancient global practice …
Article scientifique
Antibacterial activities of triterpenoidal compounds isolated from Calothamnus quadrifidus leaves
BACKGROUND: Calothamnus quadrifidus R.Br has many traditional uses and there are few reports about its chemical and biological activities. So …
Article scientifique
Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves
BACKGROUND: The plant Holarrhena floribunda (H. floribunda; G. Don) is indigenous to sub-Saharan Africa and is traditionally used to treat …
Article scientifique
Avoiding pitfalls in determining antimicrobial activity of plant extracts and publishing the results
BACKGROUND: There is an urgent need to discover new antimicrobial compounds or extracts to address the crucial problem of increasing …
Article scientifique
Effect of fractioning on antibacterial activity of n-butanol fraction from Enantia chlorantha stem bark methanol extract
Enantia chlorantha is a plant belonging to Annonaceae Family. The Barks and leaves are used traditionally to treat infectious diseases. …
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