27 publication(s) trouvée(s)
Article scientifique
Effect of altitude of coffee plants on the composition of fatty acids of green coffee beans
BACKGROUND: The fatty acids of green coffee beans are one of the major components that determine the quality of coffee. …
Article scientifique
Primary validation of Charm II tests for the detection of antimicrobial residues in a range of aquaculture fish
and the parameters determined included: detection capability, repeatability, reproducibility, specificity and robustness for the detection of antimicrobial residues in fish. …
Article scientifique
Synthesis of new 2-amino-1,3,4-oxadiazole derivatives with anti-salmonella typhi activity evaluation
Abstract Reaction of phenyl acetic acid derivatives with thiosemicarbazide in the presence of POCl3 afforded 5-(4-bromobenzyl)-1,3,4-oxadiazole-2-amine 1 and 5-(3-nitrophenyl)-1,3,4-oxadiazole -2-amine …
Article scientifique
Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities
Abstract Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, …
Article scientifique
Eco-friendly approach to access of quinoxaline derivatives using nanostructured pyrophosphate Na2PdP2O7 as a new, efficient and reusable heterogeneous catalyst
Abstract In the present study, we report the synthesis of various quinoxaline derivatives from direct condensation of substituted aromatic 1,2-diamine …
Article scientifique
Facile synthesis and antiproliferative activity of new 3-cyanopyridines
Abstract Background Pyridines have been reported to possess various pharmacological activities. Results Sodium 3-oxo-3-(2-oxo-2H-chromen-3-yl)prop-1-en-1-olate (2) and sodium 3-oxo-3-(3-oxo-3H-benzo[f]chromen-2-yl)prop-1-en-1-olate (7) were …
Article scientifique
Mechanistic formation of hazardous molecular heterocyclic amines from high temperature pyrolysis of model biomass materials: cellulose and tyrosine
BACKGROUND: Research inventories on the co-pyrolysis of major biomass components such as cellulose with amino acid materials is scarce in …
Article scientifique
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
Abstract Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, …
Article scientifique
Benzimidazole Schiff base derivatives: synthesis, characterization and antimicrobial activity
Abstract A series of Schiff bases (3.a–f) bearing benzimidazole moiety was successfully synthesized in ethanol by refluxing Oct-2-ynoic acid (1,3-dihydrobenzimidazole-2-ylidene)amide …
Article scientifique
New potentiometric sensors for methylphenidate detection based on host–guest interaction
Abstract The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and …
Article scientifique
Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet
Abstract In the present study two different RSLC columns, Acclaim RSLC 120 C18, 5.0 µm, 4.6 × 150 mm (column …
Article scientifique
Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, …
Article scientifique
Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives
Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and …
Article scientifique
Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC
Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will …
Article scientifique
Thermodynamic pathway of lignocellulosic acetylation process
The use of natural cellulosic fibers as materials in the reinforcements of polymer composites and sorption of oil from water, …
Article scientifique
A UPLC/DAD method for simultaneous determination of empagliflozin and three related substances in spiked human plasma
A simple, rapid and sensitive ultrahigh performance liquid chromatographic method was developed for the determination of the anti-diabetic drug: empagliflozin …
Article scientifique
Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
Comtrex ® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This …
Article scientifique
Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study
Highly sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous estimation of the …
Article scientifique
Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler
One of the major causes of mortality all over the world is chronic obstructive pulmonary disease (COPD). Recently approved combined …
Article scientifique
Copper doped zeolite composite for antimicrobial activity and heavy metal removal from waste water
BACKGROUND: The existence of heavy metals and coliform bacteria contaminants in aquatic system of Akaki river basin, a sub city …
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