22 publication(s) trouvée(s)
Article scientifique
Facile synthesis and antiproliferative activity of new 3-cyanopyridines
Abstract Background Pyridines have been reported to possess various pharmacological activities. Results Sodium 3-oxo-3-(2-oxo-2H-chromen-3-yl)prop-1-en-1-olate (2) and sodium 3-oxo-3-(3-oxo-3H-benzo[f]chromen-2-yl)prop-1-en-1-olate (7) were …
Article scientifique
Mechanistic formation of hazardous molecular heterocyclic amines from high temperature pyrolysis of model biomass materials: cellulose and tyrosine
BACKGROUND: Research inventories on the co-pyrolysis of major biomass components such as cellulose with amino acid materials is scarce in …
Article scientifique
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
Abstract Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, …
Article scientifique
Benzimidazole Schiff base derivatives: synthesis, characterization and antimicrobial activity
Abstract A series of Schiff bases (3.a–f) bearing benzimidazole moiety was successfully synthesized in ethanol by refluxing Oct-2-ynoic acid (1,3-dihydrobenzimidazole-2-ylidene)amide …
Article scientifique
New potentiometric sensors for methylphenidate detection based on host–guest interaction
Abstract The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and …
Article scientifique
Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet
Abstract In the present study two different RSLC columns, Acclaim RSLC 120 C18, 5.0 µm, 4.6 × 150 mm (column …
Article scientifique
Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form
Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, …
Article scientifique
Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives
Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and …
Article scientifique
Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC
Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will …
Article scientifique
Thermodynamic pathway of lignocellulosic acetylation process
The use of natural cellulosic fibers as materials in the reinforcements of polymer composites and sorption of oil from water, …
Article scientifique
A UPLC/DAD method for simultaneous determination of empagliflozin and three related substances in spiked human plasma
A simple, rapid and sensitive ultrahigh performance liquid chromatographic method was developed for the determination of the anti-diabetic drug: empagliflozin …
Article scientifique
Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
Comtrex ® tablets composed of paracetamol, pseudoephedrine and brompheniramine are widely used for relieving symptoms related to common cold. This …
Article scientifique
Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study
Highly sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous estimation of the …
Article scientifique
Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler
One of the major causes of mortality all over the world is chronic obstructive pulmonary disease (COPD). Recently approved combined …
Article scientifique
Copper doped zeolite composite for antimicrobial activity and heavy metal removal from waste water
BACKGROUND: The existence of heavy metals and coliform bacteria contaminants in aquatic system of Akaki river basin, a sub city …
Article scientifique
Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group
Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide …
Article scientifique
Salting-out assisted liquid–liquid extraction for the determination of ciprofloxacin residues in water samples by high performance liquid chromatography–diode array detector
The occurrence of emerging pollutants like pharmaceuticals and related compounds in the aquatic and terrestrial environments is of increasing concern. …
Article scientifique
Vibrational spectral analysis, XRD-structure, computation, exo⇔endo isomerization and non-linear optical crystal of 5-((5-chloro-1H-indol-2-yl)methylene)-1,3-diethyl-2-thioxodihy-dropyrimidine-4,6 (1H,5H)-dione
This work deals with the synthesis and characterization of the novel 5-((5-chloro-1H-indol-2-yl)methylene)-1,3-diethyl-2-thioxodihydro-pyrimidine-4,6(1H,5H)-dione π-bridge (D–A–D) donor–acceptor–donor compound. Its exo-isomer structure has …
Article scientifique
Computational studies of 2-(4-oxo-3-phenylthiazolidin-2-ylidene)malononitrile
) is calculated using DFT B3LYP/6-311G(d, p) method. The calculated geometric parameters are in good agreement with the experimental data. …
Article scientifique
QSAR-based rational discovery of novel substituted-4′-iminospiro[indoline-3,3′-[1,2,5]thiadiazolidinyl]-2-one 1′,1′-dioxide with potent in vitro anticancer activity
Recent studies have suggested that aldose reductase inhibition preferentially inhibits the growth of cancer cells. However, the investigations of this …
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