Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
Article scientifique
Open Access
Phillip Ssekamatte, Obondo James Sande, Reinout van Crevel
Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public …
Adult skin fibroblast state change in murine wound healing
Article scientifique
Open Access
Fatma Z. Gharbia, Ahmed S. Abouhashem, Yomna Adel Moqidem
Wound healing is a well-organized dynamic process involving coordinated consecutive phases: homeostasis, inflammation, proliferation and resolution. Fibroblasts play major roles in skin wound healing such …
Occurrence and antimicrobial resistance pattern of E. coli O157:H7 isolated from foods of Bovine origin in Dessie and Kombolcha towns, Ethiopia
Article scientifique
Open Access
Engidaw Abebe, Getachew Gugsa, Meselu Ahmed
E. coli are frequently isolated food-borne pathogens from meat, milk, and their products. Moreover, there has been a significant rise in the antimicrobial resistance patterns …
Involving men in cervical cancer prevention; a qualitative enquiry into male perspectives on screening and HPV vaccination in Mid-Western Uganda
Article scientifique
Open Access
Marlieke de Fouw, Yaël Stroeken, Ben Niwagaba
INTRODUCTION: Evidence-based preventive strategies for cervical cancer in low-resource setting have been developed, but implementation is challenged, and uptake remains low. Women and girls experience …
The regional implications of just transition in the world's most coal-dependent economy: The case of Mpumalanga, South Africa
Article scientifique
Open Access
Etienne Nel, Lochner Marais, Zolile Mqotyana
Introduction South Africa has had an extraordinarily heavy reliance on coal to fuel its economy, and it is one of the highest carbon dioxide emitters …
Diversity and functional analysis of rumen and fecal microbial communities associated with dietary changes in crossbreed dairy cattle
Article scientifique
Open Access
Felix Kibegwa, Rawlynce Cheruiyot Bett, C.K. Gachuiri
The objective of this study was to investigate the effect of varying roughage and concentrate proportions, in diet of crossbreed dairy cattle, on the composition …
Systematic review and individual-patient-data meta-analysis of non-invasive fibrosis markers for chronic hepatitis B in Africa
Article scientifique
Open Access
Asgeir Johannessen, Alexander Stockdale, Marc Henrion
In sub-Saharan Africa, simple biomarkers of liver fibrosis are needed to scale-up hepatitis B treatment. We conducted an individual participant data meta-analysis of 3,548 chronic …
Soil organic carbon, total nitrogen stocks and CO2 emissions in top- and subsoils with contrasting management regimes in semi-arid environments
Article scientifique
Open Access
Chukwuebuka Christopher Okolo, Girmay Gebresamuel, Amanuel Zenebe
Abstract This study aims to investigate soil organic carbon (SOC) and total nitrogen (TN) contents and stocks, CO2emissions and selected soil properties in croplands, grazing …
Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease
Article scientifique
Open Access
Alex Kayongo, Nicole Robertson, Trishul Siddharthan
Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global mortality, with three million deaths reported annually. This impact is expected to increase over the …
Artificial intelligence models for prediction of monthly rainfall without climatic data for meteorological stations in Ethiopia
Article scientifique
Open Access
Wondmagegn Taye Abebe, Demeke Endalie
Abstract Global climate change is affecting water resources and other aspects of life in many countries. Rainfall is the most significant climate element affecting the …
Multi-level manifestations of sexual stigma among men with same-gender sexual experience in Ghana
Article scientifique
Open Access
Khalida Saalim, Prince Amu-Adu, Richard Panix Amoh-Otu
Sexual stigma and discrimination toward men who have same-gender sexual experiences are present across the globe. In Ghana, same-gender sexual desires and relationships are stigmatized, …
Rapidly shifting immunologic landscape and severity of SARS-CoV-2 in the Omicron era in South Africa
Article scientifique
Open Access
Kaiyuan Sun, Stefano Tempia, Jackie Kleynhans
South Africa was among the first countries to detect the SARS-CoV-2 Omicron variant. However, the size of its Omicron BA.1 and BA.2 subvariants (BA.1/2) wave …
Socioeconomic factors impact the risk of HIV acquisition in the township population of South Africa: A Bayesian analysis
Article scientifique
Open Access
Cindy Leung Soo, Nitika Pant Pai, Susan J. Bartlett
With a prevalence almost twice as high as the national average, people living in South African townships are particularly impacted by the HIV epidemic. Yet, …
Novavax NVX-COV2373 triggers neutralization of Omicron sub-lineages
Article scientifique
Open Access
Jinal N. Bhiman, Simone I. Richardson, Bronwen E. Lambson
The SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern (VOC) and its sub-lineages (including BA.2, BA.4, BA.5, BA.2.12.1) contain spike mutations that confer high level resistance to …
Food insecurity and coping strategies and their association with anxiety and depression: a nationally representative South African survey
Article scientifique
Open Access
Siphiwe N. Dlamini, Ashleigh Craig, Asanda Mtintsilana
Abstract Objective: To investigate food insecurity and related coping strategies among South African households and their associations with anxiety and depression. Design: Cross-sectional study. Food …
Prevalence of diarrheal disease and associated factors among under-five children in flood-prone settlements of Northwest Ethiopia: A cross-sectional community-based study
Article scientifique
Open Access
Tsegaye Adane Birhan, Bikes Destaw Bitew, Henok Dagne
Background Diarrheal illnesses are a long-standing public health problem in developing countries due to numerous sanitation issues and a lack of safe drinking water. Floods …
Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots
Article scientifique
Open Access
Sangam L. Dwivedi, Ana Luísa Garcia‐Oliveira, Mahalingam Govindaraj
Malnutrition results in enormous socio-economic costs to the individual, their community, and the nation's economy. The evidence suggests an overall negative impact of climate change …
Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats
Article scientifique
Open Access
Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Akingbolabo Daniel Ogunlakin
Abstract Cadmium is a highly neurotoxic heavy metal that disrupts membranes and causes oxidative stress in the brain. The study aimed to investigate the neuroprotective …
The effects of COVID-19 lockdown measures on health and healthcare services in Uganda
Article scientifique
Open Access
David Musoke, Sarah Nalinya, Grace Biyinzika Lubega
Many countries across the world instituted lockdowns as a measure to prevent the spread of COVID-19. However, these lockdowns had consequences on health systems. This …
The macroevolutionary impact of recent and imminent mammal extinctions on Madagascar
Article scientifique
Open Access
Nathan M. Michielsen, Steven M. Goodman, Voahangy Soarimalala
Many of Madagascar's unique species are threatened with extinction. However, the severity of recent and potential extinctions in a global evolutionary context is unquantified. Here, …