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Value of global longitudinal peak systolic strain derived by 2-D speckle tracking in detection of obstructive coronary artery disease

Article scientifique 2023 Anglais

Résumé

Abstract Background: Early detection of obstructive coronary artery disease (CAD) using Peak Systolic global longitudinal strain derived by 2-D Speckle Tracking in patients with chronic stable angina. 75 patients with chronic stable angina were enrolled in this cross sectional study, (Mean age was 56.69 ± 6.96 y, 35 were males), 42.7 % were diabetic and all patients were assessed by thorough history taking, clinical examination,12 lead surface ECG, conventional, speckle Echocardiography and coronary angiography in Mansoura specialized medical hospital from march 2017 to October 2017 Results: Statistically significant decrease was found in GLS-Avg values in patients with obstructive CAD when compared to patients with normal coronary angiography (p<0001) and in patients with 3 or more risk factors when compared to patients with one or two risk factors (p=0.014), And when syntax score was increasing among patients with obstructive CAD a significant decrease in median GLS-Avg values was noted (p<0.001), but when regional systolic strain values were compared to affected coronary arteries no significant difference was found (p=0.844) i.e almost identical correlation between affected segments by speckle tracking and obstructed arteries by coronary angiography. Multivariate logistic regression analysis showed that GLS-Avg was found as a predictor for CAD disease in patients with chronic stable angina (p=0.028 with odds ratio 31.4 and 95% CI (1.85-535)) ROC curves were established and cutoff value was determined for GLS-Avg as -16 with 89.8% sensitivity and 100% specificity Conclusion: longitudinal strain derived by speckle tracking can be used as non-invasive simple test for evaluation of patients with chronic stable angina and as a predictor for presence or absence of obstructive CAD

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Areed, M., Yossof, M., Wadie, M. (2023). Value of global longitudinal peak systolic strain derived by 2-D speckle tracking in detection of obstructive coronary artery disease. https://doi.org/10.21203/rs.3.rs-2799556/v1

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Auteur(s)

Mohamed Fayez Areed Mahmoud Mohammed Abdo Yossof Moheb Wadie

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