Accès ouvert

Helicobacter pylori strains from a Nigerian cohort show divergent antibiotic resistance rates and a uniform pathogenicity profile

Article scientifique 2017 Anglais

Résumé

Antibiotic resistance in Helicobacter pylori is a factor preventing its successful eradication. Particularly in developing countries, resistance against commonly used antibiotics is widespread. Here, we present an epidemiological study from Nigeria with 111 isolates. We analyzed the associated disease outcome, and performed a detailed characterization of these isolated strains with respect to their antibiotic susceptibility and their virulence characteristics. Furthermore, statistical analysis was performed on microbiological data as well as patient information and the results of the gastroenterological examination. We found that the variability concerning the production of virulence factors between strains was minimal, with 96.4% of isolates being CagA-positive and 92.8% producing detectable VacA levels. In addition, high frequency of bacterial resistance was observed for metronidazole (99.1%), followed by amoxicillin (33.3%), clarithromycin (14.4%) and tetracycline (4.5%). In conclusion, this study indicated that the infection rate of H. pylori infection within the cohort in the present study was surprisingly low (36.6%). Furthermore, an average gastric pathology was observed by histological grading and bacterial isolates showed a uniform pathogenicity profile while indicating divergent antibiotic resistance rates.

Citer ce document

Harrison, U., Fowora, M., Seriki, A., Loell, E., Mueller, S., Ugo-Ijeh, M., Onyekwere, C., Lesi, O., Otegbayo, J., Akere, A., Ndububa, D., Adekanle, O., Anomneze, E., Abdulkareem, F., Adeleye, I., Crispin, A., Rieder, G., Fischer, W., Smith, S., Haas, R. (2017). Helicobacter pylori strains from a Nigerian cohort show divergent antibiotic resistance rates and a uniform pathogenicity profile. https://doi.org/10.1371/journal.pone.0176454

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Ute Harrison Muinah Fowora A. Seriki Eva Loell Susanna Mueller Margaret Ugo-Ijeh Charles Onyekwere Olufunmilayo Lesi J A Otegbayo Adegboyega Akere D A Ndububa Olusegun Adekanle Ebere Anomneze FB Abdulkareem Isaac Adeyemi Adeleye Alexander Crispin Gabriele Rieder Wolfgang Fischer Stella Smith Rainer Haas

Statistiques

Consultations : 1

Téléchargements : 0