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HLA DRB1*03 as a possible common etiology of schizophrenia, Graves’ disease, and type 2 diabetes

Article scientifique 2017 Anglais

Résumé

BACKGROUND: Autoimmune diseases and schizophrenia share many common features. Association studies confirm a shared genetic association in the human leukocyte antigen (HLA) region between schizophrenia and most autoimmune diseases. To our knowledge, the simultaneous syndromes of Graves' disease (GD) and type 2 diabetes (T2D) in schizophrenia are rare in Tunisia. CASE PRESENTATION: We report a case of a 42-year-old woman admitted to the department of psychiatry for an acute relapse of chronic schizophrenia. Her medical history revealed that she was followed for Graves' disease and for a type 2 diabetes mellitus. A low-resolution HLA typing was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) techniques according to determine the patient's haplotype. CONCLUSIONS: Our study suggests that the HLA DRB1*03 allele may explain a common etiology underlying the co-morbidity of Graves' disease, type 2 diabetes, and schizophrenia in our patient.

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Sayeh, A., Cheikh, C., Mardessi, A., Mrad, M., Nsiri, B., Oumaya, A., Fekih‐Mrissa, N. (2017). HLA DRB1*03 as a possible common etiology of schizophrenia, Graves’ disease, and type 2 diabetes. https://doi.org/10.1186/s12991-017-0128-4

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Auteur(s)

Aicha Sayeh C. Ben Cheikh Ali Mardessi Meriem Mrad B Nsiri A. Oumaya Najiba Fekih‐Mrissa

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