Accès ouvert

HIV status alters immune cell infiltration and activation profile in women with breast cancer

Article scientifique 2025 Anglais

Résumé

Abstract The breast cancer (BC)-related mortality is higher and the immunity is altered in women living with HIV (WLWH) compared to HIV-negative women. Therefore, tumor samples of 296 black BC patients from South Africa and Namibia with known age, HIV status, tumor stage, hormone receptor and HER2 status and overall survival (OS) are analyzed for components of the tumor microenvironment (TME). WLWH (n = 117), either with suppressed viral activity (HR = 1.25) or with immune suppression (HR = 2.04), have a shorter OS. HIV status is associated with increased numbers of CD8+ T cells in the TME compared to HIV-negative patients; no correlation is found with CD4+ T cell numbers in the blood. Moreover, an increased expression of CD276/B7-H3 and a more pronounced IFN-γ signaling in the tumors are found in WLWH, independent of age, stage, and BC subtypes. In conclusion, altered T cell composition and CD276 expression in WLWH may contribute to inferior survival and can be used for targeted treatment.

Citer ce document

Bauer, M., Santos, P., Wilfer, A., Berg, E., Zietsman, A., Vetter, M., Kaufhold, S., Wickenhauser, C., dos‐Santos‐Silva, I., Chen, W., Cubasch, H., Murugan, N., McCormack, V., Joffe, M., Seliger, B., Kantelhardt, E. (2025). HIV status alters immune cell infiltration and activation profile in women with breast cancer. https://doi.org/10.1038/s41467-025-59408-8

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Marcus Bauer Pablo Sandro Carvalho Santos Andreas Wilfer Eunice J. van den Berg Annelle Zietsman Martina Vetter Sandy Kaufhold Claudia Wickenhauser Isabel dos‐Santos‐Silva Wenlong Carl Chen Herbert Cubasch Nivashini Murugan Valerie McCormack Maureen Joffe Barbara Seliger Eva Johanna Kantelhardt

Statistiques

Consultations : 1

Téléchargements : 0