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Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique

Article scientifique 2020 Anglais

Résumé

Abstract Antibody transplacental transfer is essential for conferring protection in newborns against infectious diseases. This transfer may be affected by gestational age and maternal infections, although the effects are not consistent across studies. We measured total IgG and IgG subclasses by quantitative suspension array technology against fourteen pathogens and vaccine antigens, including target of maternal immunization, in 341 delivering HIV− and HIV+ mother-infant pairs from southern Mozambique. Maternal antibody levels were the main determinant of cord antibody levels. HIV broadly reduced the placental transfer and cord levels of IgG and IgG1, but also IgG2 to half of the antigens. Plasmodium falciparum exposure and prematurity were negatively associated with cord antibody levels and placental transfer but this was antigen-subclass dependent. These findings suggest maternal infections may impact the efficacy of maternal immunization and confirm the lower transfer of antibodies as one of the causes underlying increased susceptibility to infections in HIV-exposed infants.

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Alonso, S., Vidal, M., Ruiz‐Olalla, G., González, R., Manaca, M., Jairoce, C., Vázquez-Santiago, M., Balcells, R., Valá, A., Rupérez, M., Cisteró, P., Fuente, L., Cova, M., Angov, E., Nhacolo, A., Sevene, E., Aponte, J., Macete, E., Aguilar, R., Mayor, A., Menéndez, C., Dobaño, C., Moncunill, G. (2020). Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique. https://doi.org/10.1101/2020.08.05.237503

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Auteur(s)

Selena Alonso Marta Vidal Gemma Ruiz‐Olalla Raquel González Maria Nélia Manaca Chenjerai Jairoce Miquel Vázquez-Santiago Reyes Balcells Anifa Valá María Rupérez Pau Cisteró Laura de la Fuente Marta Cova Evelina Angov Arsénio Nhacolo Esperança Sevene John J. Aponte Eusébio Macete Ruth Aguilar Alfredo Mayor Clara Menéndez Carlota Dobaño Gemma Moncunill

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