Accès ouvert

Versatile and Finely Tuned Albumin Nanoplatform based on Click Chemistry

Article scientifique 2019 Anglais

Résumé

Albumin is one of the most attractive nanoplatforms for targeted imaging and drug delivery due to its biocompatibility and long circulation half-life. However, previously reported albumin-based nanoplatforms have shown inconsistent blood circulation half-life according to the modified methods, and the affecting factors were not well evaluated, which could hamper the clinical translation of albumin-based nanoplatforms. Herein, we developed a finely tuned click-chemistry based albumin nanoplatform (CAN) with a longer circulation half-life and an efficient tumor targeting ability. Methods: CAN was synthesized in two steps. First, albumin was conjugated with ADIBO-NHS (albumin-ADIBO) by reacting albumin with various molar ratios of ADIBO. The number of attached ADIBO moieties was determined using matrix-assisted laser desorption ionization time of flight (MALDI-TOF). Second, the desired modalities including azide-functionalized chelator, a fluorescence dye, and folate were incorporated into albumin-ADIBO using strain-promoted alkyne-azide cycloaddition reaction (SPAAC reaction). The biodistribution and targeting efficiency of functionalized CANs were demonstrated in mice.

Citer ce document

Park, J., Song, M., Kim, K., Lodhi, N., Choi, J., Kim, Y., Kim, J., Chung, H., Oh, C., Lee, Y., Kang, K., Im, H., Seok, S., Lee, D., Kim, E., Jeong, J. (2019). Versatile and Finely Tuned Albumin Nanoplatform based on Click Chemistry. https://doi.org/10.7150/thno.33143

Accès au document

Ce lien n'est plus accessible actuellement. Contactez l'institution d'origine.

Auteur(s)

Ji Yong Park Myung Geun Song Kyu Wan Kim Nadeem Ahmed Lodhi Jin Yeong Choi Young Ju Kim Jung Young Kim Hyewon Chung Chiwoo Oh Yun‐Sang Lee Keon Wook Kang Hyung‐Jun Im Seung Hyeok Seok Dong Soo Lee Edmund E. Kim Jae Min Jeong

Statistiques

Consultations : 3

Téléchargements : 0