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Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic

Article scientifique 2022 Anglais

Résumé

Abstract Introduction Healthcare workers (HCWs) are at high to very high risk for SARS-CoV-2 infection. The persistence of this pandemic worldwide has instigated the need for an investigation of the level of prevention through immunization and vaccination against SARS-CoV-2 among HCWs. The objective of our study was to evaluate any changes in anti-COVID-19 serological status before and after the vaccination campaign of health personnel in the Central African Republic. Method We carried out a repeated cross-sectional serological study on HCWs at the university hospital centers of Bangui. Blood samples were collected and tested for anti-SARS-CoV-2 IgM and IgG using the ELISA technique on blood samples. Results A total of 179 and 141 HCWs were included in the first and second surveys, respectively. Of these staff, 31.8% of HCWs were positive for anti-SARS-CoV-2 IgG in the first survey, whereas 95.7% were positive for anti-SARS-CoV-2 IgG in the second survey. However, the proportion of HCWs positive for SARS-CoV-2 IgM antibodies was low (9.7% in the first survey and 3.6% in the second survey). Conclusion These findings showed a sharp increase in seroprevalence over a one-year period. This increase is primarily due to the synergistic effect of the infection and the implementation of vaccines against COVID-19. Further studies to assess the persistence of anti-SARS-CoV-2 antibodies are needed.

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Manirakiza, A., Malaka, C., Mossoro-Kpinde, H., Yambiyo, B., Mossoro‐Kpinde, C., Fandema, E., Yakola, C., Doyama-Woza, R., Kangale-Wando, I., Komba, E., Guiagassomon, S., Namsenei-Dankpea, L., Coti-Reckoundji, C., Bouhouda, M., Gody, J., Grésenguet, G., Vernet, G., Vernet, M., Nakouné, E. (2022). Seroprevalence of anti-SARS-CoV-2 antibodies before and after implementation of anti-COVID-19 vaccination among hospital staff in Bangui, Central African Republic. https://doi.org/10.1101/2022.12.22.22283871

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Auteur(s)

Alexandre Manirakiza Christian Malaka Hermione Dahlia Mossoro-Kpinde Brice Martial Yambiyo Christian Diamant Mossoro‐Kpinde Emmanuel Fandema Christelle Niamathe Yakola Rodrigue Doyama-Woza Ida Maxime Kangale-Wando Elliot Kosh Komba Sandra Manuella Bénedicte Nzapali Guiagassomon Lydie Joella-Venus de la Grace Namsenei-Dankpea Cathy Sandra Gomelle Coti-Reckoundji Modeste Bouhouda Jean-Chrisostome Gody Gérard Grésenguet Guy Vernet Marie-Astrid Vernet Emmanuel Nakouné

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