Accès ouvert

TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity

Article scientifique 2025 Anglais

Résumé

BACKGROUND: Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity. METHODS: Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR. RESULTS: TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p. CONCLUSIONS: This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact.

Citer ce document

Abdelgawad, M., El-Shinnawy, H., Eissa, S., Ali, N., Behairy, M., Kamel, C., Kamel, M. (2025). TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity. https://doi.org/10.1186/s12967-025-07137-3

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Mostafa Abdelnasier Abdelgawad Howayda Abd El-Hamid El-Shinnawy Sanaa Eissa N. Ali Maha Behairy Cherry Reda Kamel Marwa Mostafa Kamel

Statistiques

Consultations : 1

Téléchargements : 0