Assessment Of Nurses Knowledge And Associated Factors Toward Prevention And Management Of Cytotoxic Extravasation In Selected Public Hospitals Oncology Units, Addis Ababa, Ethiopia: A Cross Sectional Study.

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Abstract Background: Cytotoxic extravasation is a major adverse effect than the combinations of sepsis, neutropenia, mucositis and gastrointestinal disorders. Pain, immobility, irreversible damage to nerves, tissues and tendons, skin grafting and loss of extremities are the significant morbidities secondary to extravasation.Objective: The aim of this study was to assess nurse’s knowledge and associated factors toward prevention and management of cytotoxic extravasation in selected public hospitals, Addis Ababa, Ethiopia, 2021.Methods: A descriptive cross-sectional study design was conducted at Tikur Anbessa Specialized Hospital and Saint Paul Hospital Millennium Medical College that was purposely selected. A convenience sampling technique was employed for the selection of study participants. The data were collected by using a structured self-administered questionnaire. Data entry and cleaning were done by using Epi-Data version 4.6 and SPSS version 25. A logistic regression analysis technique was employed to evaluate the effect of independent variables on the dependent variable. Statistical significance was declared at p</=0.05. The data description is presented in the text, tables and graphic representation.Result: A total of 124 nurses voluntarily participated in the study with a response rate of 93.2% and 58.1% were female nurses. The majority (45.2%) of study participants are from the age group of 20-29 years. The mean (±SD) age was 31.86 (±5.987) years. A total of 34.7% of respondents had a good levels of knowledge to prevent and manage cytotoxic extravasation. Nurses who received training were 6.6 times more likely to have good knowledge of the prevention and management of cytotoxic extravasation; [AOR= 6.602 (2.705-16.109)].Conclusion and recommendation: Generally 65.3% of study participants had poor knowledge of the prevention and management of cytotoxic extravasation. A high number (66.9%) of nurses’ were not trained on cytotoxic extravasation. Supporting nurses working in cancer centers with continuous training programs to enhance their knowledge on extravasation should be a primary task.

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