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Molecular detection and characterisation of mumps virus in cerebrospinal fluid in a Gauteng laboratory

Article scientifique 2016 Anglais

Résumé

The study aimed to determine the presence of mumps virus (MuV) in cerebrospinal fluid (CSF) specimens and to genetically characterise detected MuV strains. A real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the MuV F gene, and characterisation was performed by sequencing of the SH gene. Mumps virus was detected in 1.2% (3/260) of specimens. Phylogenetic analysis of one MuV strain revealed that it clustered with the Jeryl-Lynn and RIT4385 vaccine strains. As far as the authors could ascertain this is the first study to provide viral proof that these vaccine-like strains may be associated with aseptic meningitis.

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Brauer, M., Wolfaardt, M., Webber, L., Taylor, M. (2016). Molecular detection and characterisation of mumps virus in cerebrospinal fluid in a Gauteng laboratory. https://doi.org/10.4102/sajid.v31i1.102

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Auteur(s)

Marieke Brauer Marianne Wolfaardt Lynne M. Webber Maureen B. Taylor

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